Form F-6



As filed with the Securities and Exchange Commission on February 10, 2011

Registration No. 333-

_____________________

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

_____________________

FORM F-6

REGISTRATION STATEMENT

under

THE SECURITIES ACT OF 1933

For American Depositary Shares

of


SMITH & NEPHEW PLC

(Exact name of issuer of deposited securities as specified in its charter)

N/A

(Translation of issuer's name into English)


ENGLAND AND WALES

(Jurisdiction of incorporation or organization of issuer)


THE BANK OF NEW YORK MELLON

(Exact name of depositary as specified in its charter)

One Wall Street, New York, New York 10286

(212) 495-1784

(Address, including zip code, and telephone number, including area code, of depositary's principal executive offices)

_______________________

The Bank of New York Mellon

ADR Division

One Wall Street, 29th Floor

New York, New York 10286

(212) 495-1784

(Address, including zip code, and telephone number, including area code, of agent for service)


Copies to:

Peter B. Tisne, Esq.

Emmet, Marvin & Martin, LLP

120 Broadway

New York, New York 10271

(212) 238-3010

It is proposed that this filing become effective under Rule 466

[X] immediately upon filing

[ ] on (Date) at (Time).

If a separate registration statement has been filed to register the deposited shares, check the following box.  [ ]

CALCULATION OF REGISTRATION FEE

Title of each class
of Securities to be registered

Amount to be registered

Proposed
maximum aggregate price per unit (1)

Proposed
maximum  aggregate offering price (1)

Amount of registration fee

American Depositary Shares, each American Depositary Share representing Ordinary Shares, of Smith & Nephew plc

100,000,000 American Depositary Shares

$5.00

$5,000,000

$580.50

1

For the purpose of this table only the term "unit" is defined as 100 American Depositary Shares.










The prospectus consists of the proposed Form of American Depositary Receipt included as Exhibit A to the Form of Deposit Agreement filed as Exhibit 1 to this Registration Statement which is incorporated herein by reference.









PART I

INFORMATION REQUIRED IN PROSPECTUS

Item - 1.

Description of Securities to be Registered

Cross Reference Sheet

Location in Form of Receipt

Item Number and Caption

Filed Herewith as Prospectus


1.  Name and address of depositary

Introductory Article


2.  Title of American Depositary Receipts and identity of

Face of Receipt, top center

deposited securities


Terms of Deposit:



(i)  The amount of deposited securities represented

Face of Receipt, upper right corner

by one unit of American Depositary Receipts


(ii)  The procedure for voting, if any, the deposited

Articles number 15, 16 and 18

securities


(iii)  The collection and distribution of dividends

Articles number 4, 12, 13, 15 and

18


(iv)  The transmission of notices, reports and proxy

Articles number 11, 15, 16 and 18

soliciting material


(v)  The sale or exercise of rights

Articles number 13, 14, 15 and 18


(vi)  The deposit or sale of securities resulting from

Articles number 12, 13, 15, 17 and

dividends, splits or plans of reorganization

18


(vii)  Amendment, extension or termination of the

Articles number 20 and 21

deposit agreement


(viii)  Rights of holders of Receipts to inspect the

Article number 11

transfer books of the depositary and the list of

holders of Receipts


(ix)  Restrictions upon the right to transfer or

Articles number 2, 3, 4, 5, 6, 8 and

withdraw the underlying securities

22


(x)  Limitation upon the liability of the depositary

Articles number 14, 18, 19 and 21


3.  Fees and Charges

Articles number 7 and 8


Item – 2.

Available Information


Public reports furnished by issuer

Article number 11










PART II

INFORMATION NOT REQUIRED IN PROSPECTUS

Item - 3.

Exhibits

a.

Form of Deposit Agreement dated as of dated as of November 16, 1999, as amended and restated as of August 7, 2000, as amended and restated as of December 15, 2003, and as further amended and restated as of February 18, 2010, among Smith & Nephew plc, The Bank of New York Mellon as Depositary, and all Owners and holders from time to time of American Depositary Receipts issued thereunder. - Filed herewith as Exhibit 1.

b.

Form of Letter agreement among Smith & Nephew plc and The Bank of New York Mellon relating to pre-release activities. - Filed herewith as Exhibit 2.

c.

Every material contract relating to the deposited securities between the Depositary and the issuer of the deposited securities in effect at any time within the last three years. - See (a) and (b) above.

d.

Opinion of Emmet, Marvin & Martin, LLP, counsel for the Depositary, as to legality of the securities to be registered. – Filed herewith as Exhibit 4.  

e.

Certification under Rule 466. - Filed herewith as Exhibit 5.


Item - 4.

Undertakings

(a)

The Depositary hereby undertakes to make available at the principal office of the Depositary in the United States, for inspection by holders of the ADSs, any reports and communications received from the issuer of the deposited securities which are both (1) received by the Depositary as the holder of the deposited securities, and (2) made generally available to the holders of the underlying securities by the issuer.

(b)

If the amounts of fees charged are not disclosed in the prospectus, the Depositary undertakes to prepare a separate document stating the amount of any fee charged and describing the service for which it is charged and to deliver promptly a copy of such fee schedule without charge to anyone upon request. The Depositary undertakes to notify each registered holder of an ADS thirty days before any change in the fee schedule.









SIGNATURES

Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that all the requirements for filing on Form F-6 are met and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of New York, State of New York, on February 10, 2011.


Legal entity created by the agreement for the issuance of American Depositary Receipts for ordinary shares, of Smith & Nephew plc

By:

The Bank of New York Mellon,

  As Depositary



By:  /s/ Joanne F. Di Giovanni

Name:  Joanne F. Di Giovanni

Title:    Managing Director









Pursuant to the requirements of the Securities Act of 1933, SMITH & NEPHEW PLC has caused this Registration Statement to be signed on its behalf by the undersigned thereunto duly authorized, in the City of London, England on February 9, 2011.

SMITH & NEPHEW PLC


By:  /s/ Susan Henderson

Name: Susan Henderson

Title:   Company Secretary




Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities indicated on February 9, 2011.

/s/ John Buchanan

 

/s/ Robert Lucas


Name: John Buchanan

Name: Robert Lucas

Independent Non-Executive Chairman

Authorized U.S. Representative


/s/ David J. Illingworth


Name: David J. Illingworth


Executive Director, Principal Executive Officer



/s/ Adrian Hennah


Name: Adrian Hennah


Executive Director, Principal Financial

and Accounting Officer



/s/ Dr. Pamela J. Kirby


Name: Dr. Pamela J. Kirby


Independent Non-Executive Director


/s/ Geneviève Berger


Name: Geneviève Berger

Independent Non-Executive Director


/s/ Brian Larcombe


Name: Brian Larcombe

Independent Non-Executive Director


/s/ Joseph C. Papa


Name: Joseph C. Papa

Independent Non-Executive Director


/s/ Richard De Schutter


Name: Richard De Schutter

Independent Non-Executive Director



/s/ Dr. Rolf W.H. Stomberg


Name: Dr. Rolf W.H. Stomberg

Independent Non-Executive Director



/s/ Ian Barlow


Name: Ian Barlow

Independent Non-Executive Director











INDEX TO EXHIBITS

Exhibit

Number

Exhibit


1

Form of Deposit Agreement dated as of dated as of November 16, 1999, as amended and restated as of August 7, 2000, as amended and restated as of December 15, 2003, and as further amended and restated as of February 18, 2010 among Smith & Nephew plc, The Bank of New York Mellon as Depositary, and all Owners and holders from time to time of American Depositary Receipts issued thereunder.



2

Form of Letter agreement among Smith & Nephew plc and The Bank of New York Mellon relating to pre-release activities.



4

Opinion of Emmet, Marvin & Martin, LLP, counsel for the Depositary, as to legality of the securities to be registered.



   5

Certification under Rule 466.