UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549


                                  SCHEDULE 13G

                    UNDER THE SECURITIES EXCHANGE ACT OF 1934
                               (AMENDMENT NO. 1)*

                           Exact Sciences Corporation
--------------------------------------------------------------------------------
                                (Name of Issuer)

                                  Common Stock
--------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                    30063P105
                                    ---------
                                 (CUSIP Number)

                                December 31, 2005
                                -----------------
                      (Date of Event which Requires Filing
                               of this Statement)



Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

                  [   ]      Rule 13d-1(b)
                  [ X ]      Rule 13d-1(c)
                  [   ]      Rule 13d-1(d)



  *The remainder of this cover page shall be filled out for a reporting person's
  initial filing on this form with respect to the subject class of securities,
  and for any subsequent amendment containing information which would alter the
  disclosures provided in a prior cover page.

  The information required on the remainder of this cover page shall not be
  deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
  Act of 1934 ("Act") or otherwise subject to the liabilities of that section of
  the Act but shall be subject to all other provisions of the Act (however, see
  the Notes).


                                  Page 1 of 8



                                                                                  
--------------------------------------------                                            ------------------------------------------
CUSIP No. 30063P105                                             13G                     Page  2           of     8     Pages
         -------------------------------                                                     ------------    ---------
--------------------------------------------                                            ------------------------------------------

---------- -----------------------------------------------------------------------------------------------------------------------
        1  NAME OF REPORTING PERSON
           I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Sigma Capital Management, LLC
---------- -----------------------------------------------------------------------------------------------------------------------
        2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                                                            (a) |_|

                                                                                                            (b) |X|

---------- -----------------------------------------------------------------------------------------------------------------------
        3  SEC USE ONLY
---------- -----------------------------------------------------------------------------------------------------------------------
        4  CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware
-------------------- ------ ------------------------------------------------------------------------------------------------------
      NUMBER OF          5  SOLE VOTING POWER
       SHARES
    BENEFICIALLY            0
        OWNED        ------ ------------------------------------------------------------------------------------------------------
         BY              6  SHARED VOTING POWER
        EACH
      REPORTING             1,528,128 (see Item 4)
       PERSON        ------ ------------------------------------------------------------------------------------------------------
        WITH             7  SOLE DISPOSITIVE POWER

                            0
                     ------ ------------------------------------------------------------------------------------------------------
                         8  SHARED DISPOSITIVE POWER

                            1,528,128 (see Item 4)
---------- -----------------------------------------------------------------------------------------------------------------------
        9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           1,528,128 (see Item 4)
---------- -----------------------------------------------------------------------------------------------------------------------
       10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

           |_|
---------- -----------------------------------------------------------------------------------------------------------------------
       11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

           5.8% (see Item 4)
---------- -----------------------------------------------------------------------------------------------------------------------
       12  TYPE OF REPORTING PERSON*

           00
---------- -----------------------------------------------------------------------------------------------------------------------

                       *SEE INSTRUCTION BEFORE FILLING OUT


                                  Page 2 of 8



                                                                                  
--------------------------------------------                                            ------------------------------------------
CUSIP No. 30063P105                                             13G                     Page  3           of     8     Pages
         -------------------------------                                                     ------------    ---------
--------------------------------------------                                            ------------------------------------------

---------- -----------------------------------------------------------------------------------------------------------------------
        1  NAME OF REPORTING PERSON
           I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Sigma Capital Associates, LLC
---------- -----------------------------------------------------------------------------------------------------------------------
        2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                                                            (a) |_|

                                                                                                            (b) |X|

---------- -----------------------------------------------------------------------------------------------------------------------
        3  SEC USE ONLY
---------- -----------------------------------------------------------------------------------------------------------------------
        4  CITIZENSHIP OR PLACE OF ORGANIZATION

           Anguilla, British West Indies
-------------------- ------ ------------------------------------------------------------------------------------------------------
      NUMBER OF          5  SOLE VOTING POWER
       SHARES
    BENEFICIALLY            0
        OWNED        ------ ------------------------------------------------------------------------------------------------------
         BY              6  SHARED VOTING POWER
        EACH
      REPORTING             1,528,128 (see Item 4)
       PERSON        ------ ------------------------------------------------------------------------------------------------------
        WITH             7  SOLE DISPOSITIVE POWER

                            0
                     ------ ------------------------------------------------------------------------------------------------------
                         8  SHARED DISPOSITIVE POWER

                            1,528,128 (see Item 4)
---------- -----------------------------------------------------------------------------------------------------------------------
        9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           1,528,128 (see Item 4)
---------- -----------------------------------------------------------------------------------------------------------------------
       10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

           |_|
---------- -----------------------------------------------------------------------------------------------------------------------
       11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

           5.8% (see Item 4)
---------- -----------------------------------------------------------------------------------------------------------------------
       12  TYPE OF REPORTING PERSON*

           00
---------- -----------------------------------------------------------------------------------------------------------------------

                       *SEE INSTRUCTION BEFORE FILLING OUT


                                  Page 3 of 8



                                                                                  
--------------------------------------------                                            ------------------------------------------
CUSIP No. 30063P105                                             13G                     Page  4           of     8     Pages
         -------------------------------                                                     ------------    ---------
--------------------------------------------                                            ------------------------------------------

---------- -----------------------------------------------------------------------------------------------------------------------
        1  NAME OF REPORTING PERSON
           I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Steven A. Cohen
---------- -----------------------------------------------------------------------------------------------------------------------
        2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                                                            (a) |_|

                                                                                                            (b) |X|

---------- -----------------------------------------------------------------------------------------------------------------------
        3  SEC USE ONLY
---------- -----------------------------------------------------------------------------------------------------------------------
        4  CITIZENSHIP OR PLACE OF ORGANIZATION

           United States
-------------------- ------ ------------------------------------------------------------------------------------------------------
      NUMBER OF          5  SOLE VOTING POWER
       SHARES
    BENEFICIALLY            0
        OWNED        ------ ------------------------------------------------------------------------------------------------------
         BY              6  SHARED VOTING POWER
        EACH
      REPORTING             1,528,128 (see Item 4)
       PERSON        ------ ------------------------------------------------------------------------------------------------------
        WITH             7  SOLE DISPOSITIVE POWER

                            0
                     ------ ------------------------------------------------------------------------------------------------------
                         8  SHARED DISPOSITIVE POWER

                            1,528,128 (see Item 4)
---------- -----------------------------------------------------------------------------------------------------------------------
        9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           1,528,128 (see Item 4)
---------- -----------------------------------------------------------------------------------------------------------------------
       10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

           |_|
---------- -----------------------------------------------------------------------------------------------------------------------
       11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

           5.8% (see Item 4)
---------- -----------------------------------------------------------------------------------------------------------------------
       12  TYPE OF REPORTING PERSON*

           IN
---------- -----------------------------------------------------------------------------------------------------------------------


                       *SEE INSTRUCTION BEFORE FILLING OUT


                                  Page 4 of 8



ITEM 1(a)                  NAME OF ISSUER:
                           --------------

                           Exact Sciences Corporation

ITEM 1(b)                  ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES:
                           -----------------------------------------------

                           100 Campus Drive
                           Marlborough, Massachusetts 01752

ITEMS 2(a)                 NAME OF PERSON FILING:
                           ---------------------

                           This statement is filed by: (i) Sigma
                           Capital Management, LLC ("Sigma Capital
                           Management") with respect to Shares
                           beneficially owned by Sigma Capital
                           Associates, LLC ("Sigma Capital
                           Associates"); (ii) Sigma Capital Associates
                           with respect to Shares beneficially owned by
                           it; and (iii) Steven A. Cohen with respect
                           to Shares beneficially owned by Sigma
                           Capital Management and Sigma Capital
                           Associates.

ITEM 2(b)                  ADDRESS OF PRINCIPAL BUSINESS OFFICE:
                           ------------------------------------

                           The address of the principal business office
                           of (i) Mr. Cohen is 72 Cummings Point Road,
                           Stamford, Connecticut 06902, (ii) Sigma
                           Capital Management is 540 Madison Avenue,
                           New York, New York 10022 and (iii) Sigma
                           Capital Associates is P.O. Box 58, Victoria
                           House, The Valley, Anguilla, British West
                           Indies.

ITEM 2(c)                  CITIZENSHIP:
                           -----------

                           Sigma Capital Management is a Delaware limited
                           liability company. Sigma Capital Associates is an
                           Anguillan limited liability company. Mr. Cohen is a
                           United States citizen.

ITEM 2(d)                  TITLE OF CLASS OF SECURITIES:
                           ----------------------------

                           Common Stock

ITEM 2(e)                  CUSIP NUMBER:
                           ------------

                           30063P105

ITEM 3                     Not Applicable


                                   Page 5 of 8


ITEM 4                     OWNERSHIP:
                           ---------

                           The percentages used herein are calculated
                           based upon the Shares issued and outstanding
                           as of October 27, 2005 as reported on the
                           Issuer's quarterly report on Form 10-Q filed
                           with the Securities and Exchange Commission
                           by the Issuer for the quarterly period ended
                           September 30, 2005.

                           As of the close of business on December 30, 2005:

                           1. Sigma Capital Management, LLC
                           (a) Amount beneficially owned: 1,528,128
                           (b) Percent of class: 5.8%
                           (c) (i) Sole power to vote or direct the vote: -0-
                           (ii) Shared power to vote or direct the vote:
                           1,528,128
                           (iii) Sole power to dispose or direct the
                           disposition: -0-
                           (iv) Shared power to dispose or direct the
                           disposition: 1,528,128

                           2. Sigma Capital Associates, LLC
                           (a) Amount beneficially owned: 1,528,128
                           (b) Percent of class: 5.8%
                           (c) (i) Sole power to vote or direct the vote: -0-
                           (ii) Shared power to vote or direct the vote:
                           1,528,128
                           (iii) Sole power to dispose or direct the
                           disposition: -0-
                           (iv) Shared power to dispose or direct the
                           disposition: 1,528,128

                           3. Steven A. Cohen
                           (a) Amount beneficially owned: 1,528,128
                           (b) Percent of class: 5.8%
                           (c) (i) Sole power to vote or direct the vote: -0-
                           (ii) Shared power to vote or direct the vote:
                           1,528,128
                           (iii) Sole power to dispose or direct the
                           disposition: -0-
                           (iv) Shared power to dispose or direct the
                           disposition: 1,528,128


                                  Page 6 of 8


                           Sigma Capital Management and Mr. Cohen own
                           directly no Shares. Pursuant to an
                           investment management agreement, Sigma
                           Capital Management maintains investment and
                           voting power with respect to the securities
                           held by Sigma Capital Associates. Mr. Cohen
                           controls Sigma Capital Management. By reason
                           of the provisions of Rule 13d-3 of the
                           Securities Exchange Act of 1934, as amended,
                           each of Sigma Capital Management and Mr.
                           Cohen may be deemed to own beneficially
                           1,528,128 Shares (constituting approximately
                           5.8% of the Shares outstanding). Each of
                           Sigma Capital Management and Mr. Cohen
                           disclaim beneficial ownership of any of the
                           securities covered by this statement.

ITEM 5                     OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS:
                           --------------------------------------------

                           If this statement is being filed to report
                           the fact that as of the date hereof the
                           reporting person has ceased to be the
                           beneficial owner of more than five percent
                           of the class of securities, check the
                           following. |_|

ITEM 6                     OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF
                           ANOTHER PERSON:
                           --------------

                           Not Applicable

ITEM 7                     IDENTIFICATION AND CLASSIFICATION OF THE
                           SUBSIDIARY WHICH ACQUIRED THE SECURITY BEING
                           REPORTED ON BY THE PARENT HOLDING COMPANY:
                           -----------------------------------------

                           Not Applicable

ITEM 8                     IDENTIFICATION AND CLASSIFICATION OF MEMBERS
                           OF THE GROUP:
                           ------------

                           Not Applicable

ITEM 9                     NOTICE OF DISSOLUTION OF GROUP:
                           ------------------------------

                           Not Applicable

ITEM 10                    CERTIFICATION:

         By signing below the signatory certifies that, to the best of his
knowledge and belief, the securities referred to above were not acquired and are
not held for the purpose of or with the effect of changing or influencing the
control of the issuer of the securities and were not acquired and are not held
in connection with or as a participant in any transaction having that purpose or
effect.


                                  Page 7 of 8


                                    SIGNATURE

         After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.


Dated: February 14, 2006


SIGMA CAPITAL MANAGEMENT, LLC


By: /s/ Peter Nussbaum
   -----------------------------------------
Name: Peter Nussbaum
Title: Authorized Person


SIGMA CAPITAL ASSOCIATES, LLC


By: /s/ Peter Nussbaum
   -----------------------------------------
Name: Peter Nussbaum
Title: Authorized Person


STEVEN A. COHEN


By: /s/ Peter Nussbaum
   -----------------------------------------
Name: Peter Nussbaum
Title: Authorized Person

                                   Page 8 of 8