UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549


                                  SCHEDULE 13G

                    UNDER THE SECURITIES EXCHANGE ACT OF 1934
                               (AMENDMENT NO. 1)*

                           RIGEL PHARMACEUTICALS, INC.
--------------------------------------------------------------------------------
                                (Name of Issuer)

                                  Common Stock
--------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                    766559603
                                    ---------
                                 (CUSIP Number)

                                December 31, 2005
                                -----------------
                      (Date of Event which Requires Filing
                               of this Statement)



  Check the appropriate box to designate the rule pursuant to which this
  Schedule is filed:

           [ ]      Rule 13d-1(b)
           [X]      Rule 13d-1(c)
           [ ]      Rule 13d-1(d)



  *The remainder of this cover page shall be filled out for a reporting person's
  initial filing on this form with respect to the subject class of securities,
  and for any subsequent amendment containing information which would alter the
  disclosures provided in a prior cover page.

  The information required on the remainder of this cover page shall not be
  deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
  Act of 1934 ("Act") or otherwise subject to the liabilities of that section of
  the Act but shall be subject to all other provisions of the Act (however, see
  the Notes).

                                  Page 1 of 11


-----------------------                                  -----------------------
CUSIP No. 766559603                   13G                Page 2 of 11 Pages
-----------------------                                  -----------------------

---------- ---------------------------------------------------------------------
        1  NAME OF REPORTING PERSON
           I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           S.A.C. Capital Advisors, LLC
---------- ---------------------------------------------------------------------
        2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                        (a) |_|

                                                                        (b) |X|
---------- ---------------------------------------------------------------------
        3  SEC USE ONLY


---------- ---------------------------------------------------------------------
        4  CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware
--------------------- ----- ----------------------------------------------------
      NUMBER OF          5  SOLE VOTING POWER
        SHARES
     BENEFICIALLY           0
        OWNED         ----- ----------------------------------------------------
          BY             6  SHARED VOTING POWER
         EACH
      REPORTING             29,086 (see Item 4)
        PERSON        ----- ----------------------------------------------------
         WITH            7  SOLE DISPOSITIVE POWER

                            0
                      ----- ----------------------------------------------------
                         8  SHARED DISPOSITIVE POWER

                            29,086 (see Item 4)
---------- ---------------------------------------------------------------------
        9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           29,086 (see Item 4)
---------- ---------------------------------------------------------------------
       10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

           |_|

---------- ---------------------------------------------------------------------
       11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

           0.1% (see Item 4)
---------- ---------------------------------------------------------------------
       12  TYPE OF REPORTING PERSON*

           00
---------- ---------------------------------------------------------------------

                       *SEE INSTRUCTION BEFORE FILLING OUT

                                  Page 2 of 11


-----------------------                                  -----------------------
CUSIP No. 766559603                   13G                Page 3 of 11 Pages
-----------------------                                  -----------------------

---------- ---------------------------------------------------------------------
        1  NAME OF REPORTING PERSON
           I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           S.A.C. Capital Management, LLC
---------- ---------------------------------------------------------------------
        2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                        (a) |_|

                                                                        (b) |X|
---------- ---------------------------------------------------------------------
        3  SEC USE ONLY


---------- ---------------------------------------------------------------------
        4  CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware
-------------------- ------ ----------------------------------------------------
      NUMBER OF          5  SOLE VOTING POWER
       SHARES
    BENEFICIALLY            0
        OWNED        ------ ----------------------------------------------------
         BY              6  SHARED VOTING POWER
        EACH
      REPORTING             29,086 (see Item 4)
       PERSON        ------ ----------------------------------------------------
        WITH             7  SOLE DISPOSITIVE POWER

                            0
                     ------ ----------------------------------------------------
                         8  SHARED DISPOSITIVE POWER

                            29,086 (see Item 4)
---------- ---------------------------------------------------------------------
        9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           29,086 (see Item 4)
---------- ---------------------------------------------------------------------
       10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

           |_|

---------- ---------------------------------------------------------------------
       11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

           0.1% (see Item 4)
---------- ---------------------------------------------------------------------
       12  TYPE OF REPORTING PERSON*

           00
---------- ---------------------------------------------------------------------

                       *SEE INSTRUCTION BEFORE FILLING OUT

                                  Page 3 of 11


-----------------------                                  -----------------------
CUSIP No. 766559603                   13G                Page 4 of 11 Pages
-----------------------                                  -----------------------

---------- ---------------------------------------------------------------------
        1  NAME OF REPORTING PERSON
           I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           CR Intrinsic Investors, LLC
---------- ---------------------------------------------------------------------
        2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                        (a) |_|

                                                                        (b) |X|
---------- ---------------------------------------------------------------------
        3  SEC USE ONLY


---------- ---------------------------------------------------------------------
        4  CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware
-------------------- ------ ----------------------------------------------------
      NUMBER OF          5  SOLE VOTING POWER
       SHARES
    BENEFICIALLY            0
        OWNED        ------ ----------------------------------------------------
         BY              6  SHARED VOTING POWER
        EACH
      REPORTING             0 (see Item 4)
       PERSON        ------ ----------------------------------------------------
        WITH             7  SOLE DISPOSITIVE POWER

                            0
                     ------ ----------------------------------------------------
                         8  SHARED DISPOSITIVE POWER

                            0 (see Item 4)
---------- ---------------------------------------------------------------------
        9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           0 (see Item 4)
---------- ---------------------------------------------------------------------
       10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

           |_|

---------- ---------------------------------------------------------------------
       11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

           0% (see Item 4)
---------- ---------------------------------------------------------------------
       12  TYPE OF REPORTING PERSON*

           00
---------- ---------------------------------------------------------------------

                       *SEE INSTRUCTION BEFORE FILLING OUT

                                  Page 4 of 11


-----------------------                                  -----------------------
CUSIP No. 766559603                   13G                Page 5 of 11 Pages
-----------------------                                  -----------------------

---------- ---------------------------------------------------------------------
        1  NAME OF REPORTING PERSON
           I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Sigma Capital Management, LLC
---------- ---------------------------------------------------------------------
        2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                        (a) |_|

                                                                        (b) |X|
---------- ---------------------------------------------------------------------
        3  SEC USE ONLY


---------- ---------------------------------------------------------------------
        4  CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware
-------------------- ------ ----------------------------------------------------
      NUMBER OF          5  SOLE VOTING POWER
       SHARES
    BENEFICIALLY            0
        OWNED        ------ ----------------------------------------------------
         BY              6  SHARED VOTING POWER
        EACH
      REPORTING             0 (see Item 4)
       PERSON        ------ ----------------------------------------------------
        WITH             7  SOLE DISPOSITIVE POWER

                                        0
                     ------ ----------------------------------------------------
                         8  SHARED DISPOSITIVE POWER

                            0 (see Item 4)
---------- ---------------------------------------------------------------------
        9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           0 (see Item 4)
---------- ---------------------------------------------------------------------
       10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

           |_|

---------- ---------------------------------------------------------------------
       11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

           0% (see Item 4)
---------- ---------------------------------------------------------------------
       12  TYPE OF REPORTING PERSON*

           00
---------- ---------------------------------------------------------------------

                       *SEE INSTRUCTION BEFORE FILLING OUT

                                  Page 5 of 11


-----------------------                                  -----------------------
CUSIP No. 766559603                   13G                Page 6 of 11 Pages
-----------------------                                  -----------------------

---------- ---------------------------------------------------------------------
        1  NAME OF REPORTING PERSON
           I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Steven A. Cohen
---------- ---------------------------------------------------------------------
        2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                        (a) |_|

                                                                        (b) |X|
---------- ---------------------------------------------------------------------
        3  SEC USE ONLY


---------- ---------------------------------------------------------------------
        4  CITIZENSHIP OR PLACE OF ORGANIZATION

           United States
-------------------- ------ ----------------------------------------------------
      NUMBER OF          5  SOLE VOTING POWER
       SHARES
    BENEFICIALLY            0
        OWNED        ------ ----------------------------------------------------
         BY              6  SHARED VOTING POWER
        EACH
      REPORTING             29,086 (see Item 4)
       PERSON        ------ ----------------------------------------------------
        WITH             7  SOLE DISPOSITIVE POWER

                                        0
                     ------ ----------------------------------------------------
                         8  SHARED DISPOSITIVE POWER

                            29,086 (see Item 4)
---------- ---------------------------------------------------------------------
        9  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           29,086 (see Item 4)
---------- ---------------------------------------------------------------------
       10  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

           |_|

---------- ---------------------------------------------------------------------
       11  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

           0.1% (see Item 4)
---------- ---------------------------------------------------------------------
       12  TYPE OF REPORTING PERSON*

           IN
---------- ---------------------------------------------------------------------

                       *SEE INSTRUCTION BEFORE FILLING OUT

                                  Page 6 of 11


ITEM 1(a)     NAME OF ISSUER:

              Rigel Pharmaceuticals, Inc.

ITEM 1(b)     ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES:

              1180 Veterans Boulevard
              South San Francisco, California 94080

ITEMS 2(a)    NAME OF PERSON FILING:

              This statement is filed by: (i) S.A.C. Capital Advisors, LLC,
              ("SAC Capital Advisors") with respect to shares of common stock
              ("Shares") of the Issuer beneficially owned by S.A.C. Capital
              Associates, LLC ("SAC Capital Associates") and S.A.C. MultiQuant
              Fund, LLC ("SAC MultiQuant"); (ii) S.A.C. Capital Management, LLC,
              ("SAC Capital Management") with respect to Shares beneficially
              owned by SAC Capital Associates and SAC MultiQuant; (iii) CR
              Intrinsic Investors, LLC ("CR Intrinsic Investors"); (iv) Sigma
              Capital Management, LLC; and (v) Steven A. Cohen with respect to
              Shares beneficially owned by SAC Capital Advisors, SAC Capital
              Management, SAC Capital Associates, SAC MultiQuant, CR Intrinsic
              Investors, and Sigma Capital Management.

ITEM 2(b)     ADDRESS OF PRINCIPAL BUSINESS OFFICE:

              The address of the principal business office of (i) SAC Capital
              Advisors, CR Intrinsic Investors and Mr. Cohen is 72 Cummings
              Point Road, Stamford, Connecticut 06902 and (ii) SAC Capital
              Management and Sigma Capital Management is 540 Madison Avenue, New
              York, New York 10022.

ITEM 2(c)     CITIZENSHIP:

              SAC Capital Advisors, SAC Capital Management, CR Intrinsic
              Investors and Sigma Capital Management are Delaware limited
              liability companies. Mr. Cohen is a United States citizen.

ITEM 2(d)     TITLE OF CLASS OF SECURITIES:

              Common Stock

ITEM 2(e)     CUSIP NUMBER:

              766559603

ITEM 3        Not Applicable

                                  Page 7 of 11



ITEM 4        OWNERSHIP:

              The percentages used herein are calculated based upon the Shares
              issued and outstanding as of October 27, 2005 as reported on the
              Issuer's quarterly report on Form 10-Q/A filed with the Securities
              and Exchange Commission by the Issuer for the quarter period ended
              September 30, 2005.

              As of the close of business on December 30, 2005:

              1. S.A.C. Capital Advisors, LLC
              (a) Amount beneficially owned: 29,086
              (b) Percent of class: 0.1%
              (c) (i) Sole power to vote or direct the vote: -0-
              (ii) Shared power to vote or direct the vote: 29,086
              (iii) Sole power to dispose or direct the disposition: -0-
              (iv) Shared power to dispose or direct the disposition: 29,086

              2. S.A.C. Capital Management, LLC
              (a) Amount beneficially owned: 29,086
              (b) Percent of class: 0.1%
              (c) (i) Sole power to vote or direct the vote: -0-
              (ii) Shared power to vote or direct the vote: 29,086
              (iii) Sole power to dispose or direct the disposition: -0-
              (iv) Shared power to dispose or direct the disposition: 29,086

              3. CR Intrinsic Investors, LLC
              (a) Amount beneficially owned: -0-
              (b) Percent of class: 0%
              (c) (i) Sole power to vote or direct the vote: -0-
              (ii) Shared power to vote or direct the vote: -0-
              (iii) Sole power to dispose or direct the disposition: -0-
              (iv) Shared power to dispose or direct the disposition: -0-

              4. Sigma Capital Management, LLC
              (a) Amount beneficially owned: -0-
              (b) Percent of class: 0%
              (c) (i) Sole power to vote or direct the vote: -0-
              (ii) Shared power to vote or direct the vote: -0-
              (iii) Sole power to dispose or direct the disposition: -0-
              (iv) Shared power to dispose or direct the disposition: -0-

              5. Steven A. Cohen
              (a) Amount beneficially owned: 29,086
              (b) Percent of class: 0.1%
              (c) (i) Sole power to vote or direct the vote: -0-
              (ii) Shared power to vote or direct the vote: 29,086
              (iii) Sole power to dispose or direct the disposition: -0-
              (iv) Shared power to dispose or direct the disposition: 29,086

                                  Page 8 of 11


              SAC Capital Advisors, SAC Capital Management, CR Intrinsic
              Investors, Sigma Capital Management and Mr. Cohen own directly no
              Shares. Pursuant to investment agreements, each of SAC Capital
              Advisors and SAC Capital Management share all investment and
              voting power with respect to the securities held by SAC Capital
              Associates and SAC MultiQuant. Pursuant to an investment
              management agreement, CR Intrinsic Investors maintains investment
              and voting power with respect to the securities held by CR
              Intrinsic Investments, LLC ("CR Intrinsic Investments"). Pursuant
              to an investment management agreement, Sigma Capital Management
              maintains investment and voting power with respect to the
              securities held by Sigma Capital Associates, LLC. Mr. Cohen
              controls each of SAC Capital Advisors, SAC Capital Management, CR
              Intrinsic Investors and Sigma Capital Management. CR Intrinsic
              Investments is a wholly owned subsidiary of SAC Capital
              Associates. By reason of the provisions of Rule 13d-3 of the
              Securities Exchange Act of 1934, as amended, each of (i) SAC
              Capital Advisors, SAC Capital Management and Mr. Cohen may be
              deemed to own beneficially 29,086 Shares (constituting
              approximately 0.1% of the Shares outstanding); (ii) CR Intrinsic
              Investors and Mr. Cohen may be deemed to own beneficially 0
              Shares; and (iii) Sigma Capital Management and Mr. Cohen may be
              deemed to own beneficially 0 Shares. Each of SAC Capital Advisors,
              SAC Capital Management, CR Intrinsic Investors, Sigma Capital
              Management, and Mr. Cohen disclaim beneficial ownership of any of
              the securities covered by this statement, and SAC Capital
              Associates disclaims beneficial ownership of any securities held
              by CR Intrinsic Investments.

ITEM 5        OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS:

              If this statement is being filed to report
              the fact that as of the date hereof the
              reporting person has ceased to be the
              beneficial owner of more than five percent
              of the class of securities, check the
              following. |X|

ITEM 6        OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON:

              Not Applicable

                                  Page 9 of 11


ITEM 7        IDENTIFICATION AND CLASSIFICATION OF THE
              SUBSIDIARY WHICH ACQUIRED THE SECURITY BEING
              REPORTED ON BY THE PARENT HOLDING COMPANY:

              Not Applicable

ITEM 8        IDENTIFICATION AND CLASSIFICATION OF MEMBERS
              OF THE GROUP:

              Not Applicable

ITEM 9        NOTICE OF DISSOLUTION OF GROUP:

              Not Applicable

ITEM 10       CERTIFICATION:

     By signing below the signatory certifies that, to the best of his
knowledge and belief, the securities referred to above were not acquired and are
not held for the purpose of or with the effect of changing or influencing the
control of the issuer of the securities and were not acquired and are not held
in connection with or as a participant in any transaction having that purpose or
effect.


                                 Page 10 of 11


                                    SIGNATURE

     After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

Dated:  February 14, 2006


S.A.C. CAPITAL ADVISORS, LLC


By: /s/ Peter Nussbaum
   -----------------------------------------
Name:   Peter Nussbaum
Title:  Authorized Person


S.A.C. CAPITAL MANAGEMENT, LLC


By: /s/ Peter Nussbaum
   -----------------------------------------
Name:   Peter Nussbaum
Title:  Authorized Person


CR INTRINSIC INVESTORS, LLC


By: /s/ Peter Nussbaum
   -----------------------------------------
Name:   Peter Nussbaum
Title:  Authorized Person


SIGMA CAPITAL MANAGEMENT, LLC


By: /s/ Peter Nussbaum
   -----------------------------------------
Name:   Peter Nussbaum
Title:  Authorized Person


STEVEN A. COHEN


By: /s/ Peter Nussbaum
   -----------------------------------------
Name:   Peter Nussbaum
Title:  Authorized Person


                                 Page 11 of 11