SCHEDULE 13G
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, DC 20549
Under the Securities Exchange Act of 1934
(Amendment No. )*
METABASIS THERAPEUTICS, INC.
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(Name of Issuer)
Common Stock, par value $0.001 per share
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(Title of Class of Securities)
59101M105
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(CUSIP Number)
March 30, 2006
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(Date of Event which Requires Filing of this Statement)
Check the appropriate box to designate the rule pursuant to which this
Schedule is filed:
|_| Rule 13d-1(b)
|X| Rule 13d-1(c)
|_| Rule 13d-1(d)
*The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would
alter disclosures provided in a prior cover page.
The information required on the remainder of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 (the "Act") or otherwise subject to the liabilities of that section
of the Act, but shall be subject to all other provisions of the Act (however,
see the Notes).
Page 1 of 8 Pages
CUSIP No. 59101M105
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1 NAMES OF REPORTING PERSONS
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (entities only)
Felix J. Baker
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2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
(a) |_|
(b) |X|
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3 SEC USE ONLY
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4 CITIZENSHIP OR PLACE OF ORGANIZATION
United States
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NUMBER OF 5 SOLE VOTING POWER
SHARES
BENEFICIALLY -0-
OWNED BY ------------------------------------------------------------
EACH 6 SHARED VOTING POWER
REPORTING
PERSON 2,300,028
WITH ------------------------------------------------------------
7 SOLE DISPOSITIVE POWER
-0-
------------------------------------------------------------
8 SHARED DISPOSITIVE POWER
2,300,028
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9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
2,300,028
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10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
(See Instructions)
|_|
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11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
9.0%
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12 TYPE OF REPORTING PERSON (See Instructions)
IN
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Page 2 of 8 Pages
CUSIP No. 59101M105
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1 NAMES OF REPORTING PERSONS
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (entities only)
Julian C. Baker
--------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
(a) |_|
(b) |X|
--------------------------------------------------------------------------------
3 SEC USE ONLY
--------------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
United States
--------------------------------------------------------------------------------
NUMBER OF 5 SOLE VOTING POWER
SHARES
BENEFICIALLY -0-
OWNED BY ------------------------------------------------------------
EACH 6 SHARED VOTING POWER
REPORTING
PERSON 2,300,028
WITH ------------------------------------------------------------
7 SOLE DISPOSITIVE POWER
-0-
------------------------------------------------------------
8 SHARED DISPOSITIVE POWER
2,300,028
--------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
2,300,028
--------------------------------------------------------------------------------
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
(See Instructions)
|_|
--------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
9.0%
--------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON (See Instructions)
IN
--------------------------------------------------------------------------------
Page 3 of 8 Pages
Item 1(a) Name of Issuer:
Metabasis Therapeutics Inc.
Item 1(b) Address of Issuer's Principal Executive Offices:
11119 North Torrey Pines Road
LaJolla, CA 92037
Item 2(a) Name of Person Filing:
This Schedule 13G is being filed jointly by Felix J. Baker and
Julian C. Baker (the "Reporting Persons").
Item 2(b) Address of Principal Business Office or, if None, Residence:
Name Business Address
---- ----------------
Felix J. Baker 667 Madison Avenue
New York, NY 10021
Julian C. Baker 667 Madison Avenue
New York, NY 10021
Item 2(c) Citizenship:
Each of the Reporting Persons is a United States citizen.
Item 2(d) Title of Class of Securities:
Common Stock, par value $0.001 per share
Item 2(e) CUSIP Number:
59101M105
Item 3. If this statement is filed pursuant to ss.ss.240.13d-1(b) or (c),
check whether the person filing is a: N/A
(a) |_| Broker or dealer registered under Section 15 of the Exchange
Act.
(b) |_| Bank as defined in section 3(a)(6) of the Exchange Act.
(c) |_| Insurance company as defined in section 3(a)(19) of the Exchange
Act.
(d) |_| Investment company registered under section 8 of the Investment
Company Act of 1940.
Page 4 of 8 Pages
(e) |_| An investment adviser in accordance with Rule
13d-1(b)(1)(ii)(E).
(f) |_| An employee benefit plan or endowment fund in accordance with
Rule 13d-1(b)(1)(ii)(F).
(g) |_| A parent holding company or control person in accordance with
Rule 13d-1(b)(1)(ii)(G).
(h) |_| A savings association as defined in Section 3(b) of the Federal
Deposit Insurance Act.
(i) |_| A church plan that is excluded from the definition of an
investment company under section 3(c)(14) of the Investment Company
Act of 1940.
(j) |_| Group, in accordance with Rule 13d-1(b)(1)(ii)(J).
Item 4. Ownership.
Set forth below is the aggregate number of shares of Common
Stock, held and shares that maybe acquired upon the exercise of Warrants as of
the date hereof by each of the following, together with the percentage of the
outstanding shares of Common Stock that such number represents based upon
25,325,605 shares outstanding as reported on the Company's Form 10K filed on
March 01, 2006
Percent of
Number Class
Name of Shares Outstanding
-------------------------------- ----------- -----------
Baker Bros. Investments, L.P. 45,714 0.2%
Baker Bros. Investments II, L.P. 53,957 0.2%
Baker Biotech Fund I, L.P. 588,693 2.3%
Baker Biotech Fund II, L.P. 570,641 2.2%
Baker Biotech Fund II (Z), L.P. 103,070 0.4%
Baker Biotech Fund III, L.P. 745,062 2.9%
Baker Biotech Fund III (Z), L.P. 128,656 0.5%
14159, L.P. 49,392 0.2%
Baker Tisch Investments, LP 14,843 0.1%
-------------------------------- ----------- -----------
Total 2,300,028 9.0%
By virtue of their ownership of entities that have the power
to control the investment decisions of the limited partnerships listed in the
table above, Felix J. Baker and Julian C. Baker may each be deemed to be
beneficial owners of shares owned by such entities and may be deemed to have
shared power to vote or direct the vote of and shared power to dispose or direct
the disposition of such securities.
Page 5 of 8 Pages
Item 5. Ownership of Five Percent or Less of a Class.
If this statement is being filed to report the fact that as of the
date hereof the reporting person has ceased to be the beneficial owner of more
than five percent of the class of securities, check the following |_|. N/A
Item 6. Ownership of More than Five Percent on Behalf of Another Person.
The entities listed in Item 4 above are investment funds the
investors in which have the right to receive dividends, interest and the
proceeds of sale of securities owned by such funds.
Item 7. Identification and Classification of the Subsidiary Which Acquired
the Security Being Reported on by the Parent Holding Company or
Control Person.
N/A
Item 8. Identification and Classification of Members of the Group.
N/A
Item 9. Notice of Dissolution of Group.
N/A
Item 10. Certification.
By signing below I certify that, to the best of my knowledge and
belief, the securities referred to above were not acquired and are not held for
the purpose of or with the effect of changing or influencing the control of the
issuer of the securities and were not acquired and are not held in connection
with or as a participant in any transaction having that purpose or effect.
Page 6 of 8 Pages
SIGNATURE
After reasonable inquiry and to the best of my knowledge and belief,
I hereby certify that the information set forth in this statement is true,
complete and correct.
April 10, 2006
/s/ Felix J. Baker
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Felix J. Baker
/s/ Julian C. Baker
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Julian C. Baker
Page 7 of 8 Pages
AGREEMENT
In accordance with Rule 13d-1(k)(1) under the Securities Exchange
Act of 1934, as amended, the undersigned hereby agree that this Statement on
Schedule 13G relating to the Common Stock of Metabasis Therapeutics, Inc. is
being filed with the Securities and Exchange Commission on behalf of each of
them.
April 10, 2006
/s/ Felix J. Baker
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Felix J. Baker
/s/ Julian C. Baker
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Julian C. Baker
Page 8 of 8 Pages