FORM 6-K SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 of the Securities Exchange Act of 1934 August 25, 2006 Commission File Number 001-14978 SMITH & NEPHEW plc (Registrant's name) 15 Adam Street London, England WC2N 6LA (Address of registrant's principal executive offices) [Indicate by check mark whether the registrant files or will file annual reports under cover Form 20-F or Form 40-F.] Form 20-F X Form 40-F --- --- [Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(1).] Yes No X --- --- [Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(7).] Yes No X --- --- [Indicate by check mark whether by furnishing the information contained in this Form, the registrant is also thereby furnishing information to the Commission pursuant to Rule 12g3-2 (b) under the Securities Exchange Act of 1934.] Yes No X --- --- If "Yes" is marked, indicate below the file number assigned to the registrant in connection with Rule 12g3-2 (b) : 82- n/a. SIGNATURES Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized. Smith & Nephew plc (Registrant) Date: August 25, 2006 By: /s/ Paul Chambers ----------------- Paul Chambers Company Secretary NOTIFICATION OF MAJOR INTERESTS IN SHARES 1. Name of company Smith & Nephew plc 2. Name of shareholder having a major interest The Capital Group Companies, Inc. 3. Please state whether notification indicates that it is in respect of holding of the shareholder named in 2 above or in respect of a non-beneficial interest or in the case of an individual holder if it is a holding of that person's spouse or children under the age of 18 Non-beneficial 4. Name of the registered holder(s) and, if more than one holder, the number of shares held by each of them Capital Guardian Trust Company: State Street Nominees Ltd 2,286,200 Bank Of New York Nominees Ltd 1,373,118 Northern Trust 243,500 Chase Manhattan Bank Australia Ltd 3,100 Chase Nominees Ltd 9,286,566 BT Globenet Nominees Ltd 350,100 Midland Bank plc 1,473,600 Cede & Co 113,700 Deutsche Bank Mannheim 4,500 Bankers Trust 538,145 Barclays Bank 93,000 Brown Bros 42,700 Nortrust Nominees 3,691,034 MSS Nominees Ltd 64,700 State Street Bank & Trust Co 134,500 Citibank 9,800 Citibank NA 32,000 Deutsche Bank AG 3,600 HSBC Bank plc 2,900 Mellon Bank NA 132,000 ROY Nominees Ltd 23,900 Mellon Nominees (UK) Ltd 750,400 HSBC 33,800 JP Morgan Chase Bank 954,133 Capital International Ltd: State Street Nominees Ltd 67,100 Bank of New York Nominees 1,190,517 Northern Trust 386,544 Chase Nominees Ltd 710,493 Midland Bank plc 125,600 Citibank London 13,500 Morgan Guaranty 77,500 Nortrust Nominees 762,972 MSS Nominees Limited 16,200 State Street Bank & Trust Co 362,100 Lloyds Bank 3,900 Citibank 8,300 Citibank NA 382,700 Deutsche Bank AG 24,700 HSBC Bank plc 291,265 Mellon Bank NA 28,700 Northern Trust AVFC 80,038 KAS UK 33,000 Mellon Nominees (UK) Ltd 48,600 Bank One London 48,400 JP Morgan Chase Bank 7,100 Raiffeisen Zentral Bank 348,300 Fortis Bank 10,500 Metzler Seel Sohn & Co. 8,100 Nordea Bank 75,900 Bayerische Hypo Und Vereinsbank AG 13,000 Capital International SA: Chase Nominees Ltd 452,500 Midland Bank plc 11,000 Pictet & Cie 50,100 State Street Bank & Trust Co 39,000 Lloyds Bank 18,500 HSBC Bank plc 150,900 JP Morgan Chase Bank 12,900 Metzler Seel Sohn & Co. 11,600 Capital Research and Management Company: State Street Nominees Ltd 23,381,800 Chase Nominees Ltd 109,191,771 JPM Nominees Ltd 30,000 State Street Bank & Trust Co 182,000 Capital International Inc State Street Nominees Limited 647,800 Bank of New York Nominees 243,800 Northern Trust 15,400 Chase Nominees Limited 761,000 Midland Bank 19,000 Bankers Trust 11,200 Nortrust Nominees 136,300 State Street Bank & Trust Co 47,900 Citibank 9,000 Citibank NA 132,700 HSBC Bank plc 35,400 JP Morgan Chase Bank 38,100 5. Number of shares / amount of stock acquired Not disclosed 6. Percentage of issued class Not disclosed 7. Number of shares / amount of stock disposed ................................................................ 8. Percentage of issued class ................................................................ 9. Class of security Ordinary shares of US 20 cents 10. Date of transaction 23.08.06 11. Date company informed 25.08.06 12. Total holding following this notification 162,395,696 13. Total percentage holding of issued class following this notification 17.24% 14. Any additional information ................................................................ 15. Name of contact and telephone number for queries Phil Higgins - Assistant Company Secretary 020 7960 2228 16. Name and signature of authorised company official responsible for making this notification Phil Higgins - Assistant Company Secretary Date of notification 25.08.06 The FSA does not give any express or implied warranty as to the accuracy of this document or material and does not accept any liability for error or omission. The FSA is not liable for any damages (including, without limitation, damages for loss of business or loss of profits) arising in contract, tort or otherwise from the use of or inability to use this document, or any material contained in it, or from any action or decision taken as a result of using this document or any such material.