FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person * ARMSTRONG ERNEST   2. Issuer Name and Ticker or Trading Symbol Cobalis Corp [CLSC] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __X__ Director _____ 10% Owner __X__ Officer (give title below) _____ Other (specify below) Vice President (Last) (First) (Middle) 2445 MCCABE WAY, STE 150 3. Date of Earliest Transaction (Month/Day/Year) 09/13/2005 (Street) IRVINE, CA 92614 4. If Amendment, Date Original Filed(Month/Day/Year) 6. Individual or Joint/Group Filing(Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 09/13/2005   J   12,000 (1) A $ 0.5 (2) 132,455 D   Common Stock 09/13/2005   G   12,000 (1) D $ 0.5 (2) 120,455 D   Common Stock 09/13/2005   J   12,000 (1) D $ 0.5 (2) 1,771,083 I managing member with controlling interest in Gene Pharmaceuticals Common Stock 09/13/2005   J   110,000 D $ 0.227 (3) 1,649,083 I managing member with controlling interest in Gene Pharmaceuticals LLC Common Stock               3,354 D (4)

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code (Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date (Month/Day/Year)

7. Title and Amount of Underlying Securities (Instr. 3 and 4)

8. Price of Derivative Security (Instr. 5)

9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)

11. Nature of Indirect Beneficial Ownership (Instr. 4)

Code

V

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
ARMSTRONG ERNEST 2445 MCCABE WAY STE 150 IRVINE, CA 92614	X		Vice President

Signatures

Ernest Armstrong		09/16/2005
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	On Sept 13, 2005, Gene Pharmaceuticals repaid Ernest Armstrong for a loan by transferring 12,000 of its shares in the Issuer to Mr. Armstrong. Mr. Armstrong is the managing member of Gene Pharmaceuticals. On that same date, Mr. Armstrong gifted those shares to a third party.
(2)	market price on the date of the tranasaction
(3)	value per share for 110,000 shares of the issuer's common stock which were transferred as collateral for $25,000 loan to Gene Pharmaceuticals by a third party
(4)	owned jointly with spouse

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