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UNITED
STATES
SECURITIES
AND EXCHANGE COMMISSION
Washington,
D.C. 20549
SCHEDULE
13G
Under
the Securities Exchange Act of 1934
(Amendment
No. 5)*
METABASIS
THERAPEUTICS, INC.
(Name of
Issuer)
COMMON
STOCK
(Title of
Class of Securities)
59101M105
(CUSIP
Number)
November
30, 2008
(Date of
Event Which Requires Filing of this Statement)
Check the
appropriate box to designate the rule pursuant to which this Schedule is
filed:
X Rule
13d-1(b)
____ Rule
13d-1(c)
____ Rule
13d-1(d)
*The
remainder of this cover page shall be filled out for a reporting person’s
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.
The
information required in the remainder of this cover page shall not be deemed to
be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934
(“Act”) or otherwise subject to the liabilities of that section of the Act but
shall be subject to all other provisions of the Act (however, see the
Notes).
CUSIP No.
59101M105
____________________________________________________________________________
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1.
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Names
of Reporting Persons.
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I.R.S.
Identification Nos. of above persons (entities
only).
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Federated
Investors, Inc.
2. Check
the Appropriate Box if a Member of a Group (See Instructions)
(a)
(b)
3. SEC Use
Only
4. Citizenship
or Place of Organization: Pennsylvania
Number
of 5. Sole
Voting Power 416,580
Shares
Bene-
ficially
by 6. Shared
Voting Power
Owned by
Each
Reporting 7. Sole
Dispositive Power 416,580
Person
With:
8. Shared
Dispositive Power
9. Aggregate
Amount Beneficially Owned by Each Reporting
Person 416,580
10. Check
if the Aggregate Amount in Row (9) Excludes Certain Shares (See
Instructions)
11. Percent
of Class Represented by Amount in Row (9) 1.17%
12. Type
of Reporting Person (See Instructions) HC
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1.
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Names
of Reporting Persons.
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I.R.S.
Identification Nos. of above persons (entities
only).
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Voting
Shares Irrevocable Trust
2. Check
the Appropriate Box if a Member of a Group (See Instructions)
(a)
(b)
3. SEC Use
Only
4. Citizenship
or Place of Organization: Pennsylvania
Number
of 5. Sole
Voting Power 416,580
Shares
Bene-
ficially
by 6. Shared
Voting Power
Owned by
Each
Reporting 7. Sole
Dispositive Power 416,580
Person
With:
8. Shared
Dispositive Power
9. Aggregate
Amount Beneficially Owned by Each Reporting Person 416,580
10. Check
if the Aggregate Amount in Row (9) Excludes Certain Shares (See
Instructions)
11. Percent of
Class Represented by Amount in Row (9) 1.17%
12. Type of
Reporting Person (See Instructions) OO
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1.
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Names
of Reporting Persons.
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I.R.S.
Identification Nos. of above persons (entities
only).
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John F.
Donahue
2. Check
the Appropriate Box if a Member of a Group (See Instructions)
(a)
(b)
3. SEC Use
Only
4. Citizenship
or Place of Organization: United States
Number
of 5. Sole
Voting Power
Shares
Bene-
ficially
by 6. Shared
Voting Power 416,580
Owned by
Each
Reporting 7. Sole
Dispositive Power
Person
With:
8. Shared
Dispositive Power 416,580
9. Aggregate
Amount Beneficially Owned by Each Reporting
Person 416,580
10. Check
if the Aggregate Amount in Row (9) Excludes Certain Shares (See
Instructions)
11. Percent of
Class Represented by Amount in Row (9) 1.17%
12. Type of
Reporting Person (See Instructions) IN
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1.
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Names
of Reporting Persons.
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I.R.S.
Identification Nos. of above persons (entities
only).
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Rhodora
J. Donahue
2. Check
the Appropriate Box if a Member of a Group (See Instructions)
(a)
(b)
3. SEC Use
Only
4. Citizenship
or Place of Organization: United States
Number
of 5. Sole
Voting Power
Shares
Bene-
ficially
by 6. Shared
Voting Power 416,580
Owned by
Each
Reporting 7. Sole
Dispositive Power
Person
With:
8. Shared
Dispositive Power 416,580
9. Aggregate
Amount Beneficially Owned by Each Reporting
Person 416,580
10. Check
if the Aggregate Amount in Row (9) Excludes Certain Shares (See
Instructions)
11. Percent of
Class Represented by Amount in Row (9) 1.17%
12. Type of
Reporting Person (See Instructions) IN
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1.
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Names
of Reporting Persons.
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I.R.S.
Identification Nos. of above persons (entities
only).
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J.
Christopher Donahue
2. Check
the Appropriate Box if a Member of a Group (See Instructions)
(a)
(b)
3. SEC Use
Only
4. Citizenship
or Place of Organization: United States
Number
of 5. Sole
Voting Power
Shares
Bene-
ficially
by 6. Shared
Voting Power 416,580
Owned by
Each
Reporting 7. Sole
Dispositive Power
Person
With:
8. Shared
Dispositive Power 416,580
9. Aggregate
Amount Beneficially Owned by Each Reporting
Person 416,580
10. Check
if the Aggregate Amount in Row (9) Excludes Certain Shares (See
Instructions)
11. Percent of
Class Represented by Amount in Row (9) 1.17%
12. Type of
Reporting Person (See Instructions) IN
Item
1.
(a) Name
of Issuer
METABASIS
THERAPEUTICS, INC.
(b) Address
of Issuer’s Principal Executive Offices
11119
North Torrey Pines Road
La Jolla,
CA 92037
Item
2.
(a) Name
of Person Filing
(b) Address
of Principal Business Office or, if none, Residence
Federated
Investors Tower, Pittsburgh, PA 15222-3779
(c) Citizenship
(d) Title
of Class of Securities
Common
Stock
(e) CUSIP
Number
59101M105
Item 3. If this statement is filed pursuant
to §§240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is
a:
(a) ____ Broker
or dealer registered under section 15 of the Act (15 U.S.C. 78o).
(b) ____ Bank
as defined in section 3(a)(6) of the Act (15 U.S.C. 78c).
(c) ____ Insurance
company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c).
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(d)
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____
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Investment
company registered under section 8 of the Investment Company Act of 1940
(15 U.S.C 80a-8).
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(e) ____ An
investment adviser in accordance with §240.13d-1(b)(1)(ii)(E);
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(f)
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____
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An
employee benefit plan or endowment fund in accordance with
§240.13d-1(b)(1)(ii)(F);
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(g) __X__ A
parent holding company or control person in accordance with §
240.13d-1(b)(1)(ii)(G);
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(h)
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____
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A
savings associations as defined in Section 3(b) of the Federal Deposit
Insurance Act (12 U.S.C. 1813);
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(i)
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____
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A
church plan that is excluded from the definition of an investment company
under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C.
80a-3);
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(j) ____ Group,
in accordance with §240.13d-1(b)(1)(ii)(J).
Item
4. Ownership.
Provide
the following information regarding the aggregate number and percentage of the
class of securities of the issuer identified in Item 1.
A. Federated
Investors, Inc. (See Footnote 1, next page)
(a) Amount
beneficially owned: 416,580
(b) Percent
of class: 1.17%
(c) Number
of shares as to which the person has:
(i) Sole
power to vote or to direct the vote 416,580
(ii) Shared
power to vote or to direct the vote -0-
(iii) Sole
power to dispose or to direct the disposition of 416,580
(iv) Shared
power to dispose or to direct the disposition of -0-
B. Voting
Shares Irrevocable Trust
(a) Amount
beneficially owned: 416,580
(b) Percent
of class: 1.17%
(c) Number
of shares as to which the person has:
(i) Sole
power to vote or to direct the vote 416,580
(ii) Shared
power to vote or to direct the vote -0-
(iii) Sole
power to dispose or to direct the disposition of 416,580
(iv) Shared
power to dispose or to direct the disposition of -0-
C. John
F. Donahue
(a) Amount
beneficially owned: 416,580
(b) Percent
of class: 1.17%
(c) Number
of shares as to which the person has:
(i) Sole
power to vote or to direct the vote -0-
(ii) Shared
power to vote or to direct the vote 416,580
(iii) Sole
power to dispose or to direct the disposition of -0-
(iv) Shared
power to dispose or to direct the disposition of 416,580
D.
Rhodora J. Donahue
(a) Amount
beneficially owned: 416,580
(b) Percent
of class: 1.17%
(c) Number
of shares as to which the person has:
(i) Sole
power to vote or to direct the vote -0-
(ii) Shared
power to vote or to direct the vote 416,580
(iii) Sole
power to dispose or to direct the disposition of -0-
(iv) Shared
power to dispose or to direct the disposition of 416,580
E. J.
Christopher Donahue
(a) Amount
beneficially owned: 416,580
(b) Percent
of class: 1.17%
(c) Number
of shares as to which the person has:
(i) Sole
power to vote or to direct the vote -0-
(ii) Shared
power to vote or to direct the vote 416,580
(iii) Sole
power to dispose or to direct the disposition of -0-
(iv) Shared
power to dispose or to direct the disposition of 416,580
Instruction. For
computations regarding securities which represent a right to acquire an
underlying security see
§240.13d-3(d)(1).
Item
5. Ownership of Five Percent or Less of a Class
If this
statement is being filed to report the fact that as of the date hereof the
reporting person has ceased to be the beneficial owner of more than five percent
of the class of securities, check the following _X__.
Instruction: Dissolution
of a group requires a response to this item.
Item
6. Ownership of More than Five Percent on Behalf of Another
Person. NOT APPLICABLE
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Item
7. Identification and Classification of the Subsidiary Which
Acquired the Security Being Reported on By the Parent Holding
Company See Exhibit “1”
Attached
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Item
8. Identification and Classification of Members of the Group NOT
APPLICABLE
Item
9. Notice of Dissolution of Group NOT APPLICABLE
Item
10. Certification
(a) The
following certification shall be included if the statement is filed pursuant to
§240.13d-1(b):
By
signing below I certify that, to the best of my knowledge and belief, the
securities referred to above were acquired and are held in the ordinary course
of business and were not acquired and are not held for the purpose of or with
the effect of changing or influencing the control of the issuer of the
securities and were not acquired and are not held in connection with or as a
participant in any transaction having that purpose or effect.
(b) The
following certification shall be included if the statement is filed pursuant to
§240.13d-1(c):
By
signing below I certify that, to the best of my knowledge and belief, the
securities referred to above were not acquired and are not held for the purpose
of or with the effect of changing or influencing the control of the issuer of
the securities and were not acquired and are not held in connection with or as a
participant in any transaction having that purpose or effect.
SIGNATURE
After
reasonable inquiry and to the best of my knowledge and belief, I certify that
the information set forth in this statement is true, complete and
correct.
Date: December
9, 2008
By: /s/J.
Christopher Donahue
Name/Title: J.
Christopher Donahue, as President of Federated Investors, Inc.
Date: December
9, 2008
By:
/s/John F. Donahue, individually and as Trustee of Voting Shares Irrevocable
Trust, by
J.
Christopher Donahue, as attorney-in-fact
Date: December
9, 2008
By:
/s/Rhodora J. Donahue, individually and as Trustee of Voting Shares Irrevocable
Trust, by
J.
Christopher Donahue, as attorney-in-fact
Date: December
9, 2008
By: /s/J.
Christopher Donahue
Name/Title: J.
Christopher Donahue, individually and as Trustee of Voting Shares Irrevocable
Trust
The
original statement shall be signed by each person on whose behalf the statement
is filed or his authorized representative. If the statement is signed on behalf
of a person by his authorized representative other than an executive officer or
general partner of the filing person, evidence of the representative’s authority
to sign on behalf of such person shall be filed with the statement, provided,
however, that a power of attorney for this purpose which is already on file with
the Commission may be incorporated by reference. The name and any title of each
person who signs the statement shall be typed or printed beneath his
signature.
NOTE: Schedules
filed in paper format shall include a signed original and five copies of the
schedule, including all exhibits. See §240.13d-7 for other
parties for whom copies are to be sent.
Attention:
Intentional misstatements or omissions of fact constitute Federal criminal
violations (See 18 U.S.C. 1001)
EXHIBIT
“1”
ITEM 3
CLASSIFICATION OF
REPORTING
PERSONS
Identity
and Classification of Each Reporting Person
IDENTITY CLASSIFICATION
UNDER ITEM 3
Federated
Equity
Funds (d)
Investment company registered under section 8
of the Investment Company Act of 1940
(15 U.S.C. 80a-8).
Federated
Equity Management Company of
Pennsylvania (e)
Investment Adviser registered under section
203 of the Investment Advisers Act of
1940
Federated
Global Investment Management
Corp. (e)
Investment Adviser registered under section
203 of the Investment Advisers Act of
1940
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Federated
Investors, Inc.
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(g)
Parent Holding Company, in accordance with Section
240.13d-1(b)(ii)(G)
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FII
Holdings, Inc.
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(g)
Parent Holding Company, in accordance with Section
240.13d-1(b)(ii)(G)
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Voting
Shares Irrevocable Trust
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(g)
Parent Holding Company, in accordance with Section
240.13d-1(b)(ii)(G)
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John
F. Donahue
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(g)
Parent Holding Company, in accordance with Section
240.13d-1(b)(ii)(G)
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Rhodora
J. Donahue
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(g)
Parent Holding Company, in accordance with Section
240.13d-1(b)(ii)(G)
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J.
Christopher Donahue
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(g)
Parent Holding Company, in accordance with Section
240.13d-1(b)(ii)(G)
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Federated
Investors, Inc. (the “Parent”) is filing this Schedule 13G because it is the
parent holding company of Federated Equity Management Company of Pennsylvania
and Federated Global Investment Management Corp. (the “Investment Advisers”),
which act as investment advisers to registered investment companies and separate
accounts that own shares of common stock in METABASIS THERAPEUTICS,
INC. (the “Reported Securities’). The Investment Advisers
are wholly owned subsidiaries of FII Holdings, Inc., which is wholly owned
subsidiary of Federated Investors, Inc., the Parent. All of the
Parent’s outstanding voting stock is held in the Voting Shares Irrevocable Trust
(the “Trust”) for which John F. Donahue, Rhodora J. Donahue and J. Christopher
Donahue act as trustees (collectively, the “Trustees”). The Trustees
have joined in filing this Schedule 13G because of the collective voting control
that they exercise over the Parent. In accordance with Rule 13d-4
under the Securities Act of 1934, as amended, the Parent, the Trust, and each of
the Trustees declare that this statement should not be construed as an admission
that they are the beneficial owners of the Reported Securities, and the Parent,
the Trust, and each of the Trustees expressly disclaim beneficial ownership of
the Reported Securities
EXHIBIT
“2”
AGREEMENT
FOR JOINT FILING OF
SCHEDULE
13G
The following parties hereby agree to
file jointly the statement on Schedule 13G to which this Agreement is attached
and any amendments thereto which may be deemed necessary pursuant to Regulation
13D-G under the Securities Exchange Act of 1934:
1. Federated
Investors, Inc. as parent holding company of the investment advisers to
registered investment companies that beneficially own the
securities.
Voting
Shares Irrevocable Trust, as holder of all the voting shares of Federated
Investors, Inc.
John F.
Donahue, individually and as Trustee
Rhodora
J. Donahue, individually and as Trustee
J.
Christopher Donahue, individually and as Trustee
It is understood and agreed that each
of the parties hereto is responsible for the timely filing of such statement and
any amendments thereto, and for the completeness and accuracy of the information
concerning such party contained therein, but such party is not responsible for
the completeness or accuracy of information concerning the other parties unless
such party knows or has reason to believe that such information is incomplete or
inaccurate.
It is understood and agreed that the
joint filing of Schedule 13G shall not be construed as an admission that the
reporting persons named herein constitute a group for purposes of Regulation
13D-G of the Securities Exchange Act of 1934, nor is a joint venture for
purposes of the Investment Company Act of 1940.
Date: December
9, 2008
By: /s/J.
Christopher Donahue
Name/Title:
J. Christopher Donahue, as President of Federated Investors, Inc.
By: /s/John
F. Donahue
Name/Title: John
F. Donahue, individually and as Trustee of Voting Shares Irrevocable Trust, by
J. Christopher Donahue, as attorney-in-fact.
By: /s/Rhodora
J. Donahue
Name/Title: Rhodora
J. Donahue, individually and as Trustee as Voting Shares Irrevocable Trust, by
J. Christopher Donahue, as attorney-in-fact.
By: /s/ J.
Christopher Donahue
Name/Title: J.
Christopher Donahue, individually and as Trustee of Voting Shares Irrevocable
Trust
1. The
number of shares indicated represent shares beneficially owned by registered
investment companies and separate accounts advised by subsidiaries of Federated
Investors, Inc. that have been delegated the power to direct investments and
power to vote the securities by the registered investment companies’ board of
trustees or directors and by the separate accounts’ principals. All
of the voting securities of Federated Investors, Inc. are held in the Voting
Shares Irrevocable Trust (“Trust”), the trustees of which are John F. Donahue,
Rhodora J. Donahue, and J. Christopher Donahue (“Trustees’). In
accordance with Rule 13d-4 under the 1934 Act, the Trust, Trustees, and parent
holding company declare that the filing of this statement should not be
construed as an admission that any of the investment advisers, parent holding
company, Trust, and Trustees are beneficial owners (for the purposes of Sections
13(d) and/or 13(g) of the Act) of any securities covered by this statement, and
such advisers, parent holding company, Trust, and Trustees expressly disclaim
that they are the beneficial owners such securities.
EXHIBIT
3
POWER OF
ATTORNEY
Each person who signature appears below
hereby constitutes and appoints J. Christopher Donahue their true and lawful
attorney-in-fact and agent, with full power of substitution and resubstitution
for them and in their names, place and stead, in any and all capacities, to sign
any and all Schedule 13Ds and/or Schedule 13Gs, and any amendments thereto, to
be filed with the Securities and Exchange commission pursuant to Regulation
13D-G of the Securities Exchange Act of 1934, as amended, by means of the
Securities and Exchange Commission’s electronic disclosure system known as
EDGAR; and to file the same, with all exhibits thereto and other documents in
connection therewith, with the Securities and Exchange Commission, granting unto
said attorney-in-fact and agent, full power and authority to sign and perform
each and every act and thing requisite and necessary to be done in connection
therewith, as fully to all intents and purposes as each of them might or could
do in person, hereby ratifying and confirming all that said attorney-in-fact and
agent, or their or his substitute or substitutes, may lawfully do or cause to be
done by virtue thereof.
SIGNATURES TITLE
OR CAPACITY
/s/John F.
Donahue Individually and as
Trustee of
John F.
Donahue the
Voting Shares Irrevocable Trust
/s/Rhodora J.
Donahue Individually and as
Trustee of
Rhodora
J.
Donahue the
Voting Shares Irrevocable Trust
Sworn to
and subscribed before me this 23rd day of
September, 2004.
/s/Madaline P.
Kelly
Notary
Public
My
Commission Expires: February 22, 2008