SECURITIES AND EXCHANGE COMMISSION
                      Washington, D.C. 20549
                             ----------------------

                                  SCHEDULE 13G

                    Under the Securities Exchange Act of 1934

                           Altus Pharmaceuticals Inc.
                                (Name of Issuer)

                                  Common Stock
                         (Title of Class of Securities)

                                    02216N105
                                 (CUSIP Number)

                                October 11, 2006
             (Date of event which requires filing of this statement)


     Check the appropriate box to designate the rule pursuant to which this
Schedule 13G is filed:
     [ ]  Rule 13d-1(b)
     [X]  Rule 13d-1(c)
     [ ]  Rule 13d-1(d)





                              (Page 1 of 13 Pages)
----------------
     *The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would
alter the disclosures provided in a prior cover page.

     The information required in the remainder of this cover page shall not be
deemed to be "filed" for purposes of Section 18 of the Securities Exchange Act
of 1934 ("Act") or otherwise subject to the liabilities of that section of the
Act but shall be subject to all other provisions of the Act (however, see the
Notes).






CUSIP No. 02216N105                 13G                  Page 2 of 13 Pages

-----------------------------------------------------------------------------
     (1)    NAMES OF REPORTING PERSONS
            I.R.S. IDENTIFICATION NO.
            OF ABOVE PERSONS (ENTITIES ONLY)
                                           Adage Capital Partners, L.P.
-----------------------------------------------------------------------------
     (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP **
                                                                  (a)  [ ]
                                                                  (b)  [X]
-----------------------------------------------------------------------------
     (3)    SEC USE ONLY
-----------------------------------------------------------------------------
     (4)    CITIZENSHIP OR PLACE OF ORGANIZATION
                            Delaware
-----------------------------------------------------------------------------
NUMBER OF      (5)  SOLE VOTING POWER
                                                -0-
SHARES         --------------------------------------------------------------

BENEFICIALLY   (6)  SHARED VOTING POWER
                    Warrant to purchase 1,962,494 shares of Common Stock

                    112,506 shares of Common Stock
OWNED BY       --------------------------------------------------------------

EACH           (7)  SOLE DISPOSITIVE POWER
                                                -0-
REPORTING      --------------------------------------------------------------

PERSON WITH    (8)  SHARED DISPOSITIVE POWER
                    Warrant to purchase 1,962,494 shares of Common Stock

                    112,506 shares of Common Stock
-----------------------------------------------------------------------------
     (9)    AGGREGATE AMOUNT BENEFICIALLY OWNED
            BY EACH REPORTING PERSON
            Warrant to purchase 1,962,494 shares of Common Stock

            112,506 shares of Common Stock
-----------------------------------------------------------------------------
     (10)   CHECK BOX IF THE AGGREGATE AMOUNT
            IN ROW (9) EXCLUDES CERTAIN SHARES **                       [ ]
-----------------------------------------------------------------------------
     (11)   PERCENT OF CLASS REPRESENTED
            BY AMOUNT IN ROW (9)
                                                8.4%
-----------------------------------------------------------------------------
     (12)   TYPE OF REPORTING PERSON **
                                                 PN
-----------------------------------------------------------------------------
                     ** SEE INSTRUCTIONS BEFORE FILLING OUT!






CUSIP No. 02216N105                 13G                  Page 3 of 13 Pages

-----------------------------------------------------------------------------
     (1)    NAMES OF REPORTING PERSONS
            I.R.S. IDENTIFICATION NO.
            OF ABOVE PERSONS (ENTITIES ONLY)
                                           Adage Capital Partners GP, L.L.C.
-----------------------------------------------------------------------------
     (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP **
                                                                  (a)  [ ]
                                                                  (b)  [X]
-----------------------------------------------------------------------------
     (3)    SEC USE ONLY
-----------------------------------------------------------------------------
     (4)    CITIZENSHIP OR PLACE OF ORGANIZATION
                            Delaware
-----------------------------------------------------------------------------
NUMBER OF      (5)  SOLE VOTING POWER
                                                -0-
SHARES         --------------------------------------------------------------

BENEFICIALLY   (6)  SHARED VOTING POWER
                    Warrant to purchase 1,962,494 shares of Common Stock

                    112,506 shares of Common Stock
OWNED BY       --------------------------------------------------------------

EACH           (7)  SOLE DISPOSITIVE POWER
                                                -0-
REPORTING      --------------------------------------------------------------

PERSON WITH    (8)  SHARED DISPOSITIVE POWER
                    Warrant to purchase 1,962,494 shares of Common Stock

                    112,506 shares of Common Stock
-----------------------------------------------------------------------------
     (9)    AGGREGATE AMOUNT BENEFICIALLY OWNED
            BY EACH REPORTING PERSON
            Warrant to purchase 1,962,494 shares of Common Stock

            112,506 shares of Common Stock
-----------------------------------------------------------------------------
     (10)   CHECK BOX IF THE AGGREGATE AMOUNT
            IN ROW (9) EXCLUDES CERTAIN SHARES **                       [ ]
-----------------------------------------------------------------------------
     (11)   PERCENT OF CLASS REPRESENTED
            BY AMOUNT IN ROW (9)
                                                8.4%
-----------------------------------------------------------------------------
     (12)   TYPE OF REPORTING PERSON **
                                                 OO
-----------------------------------------------------------------------------
                     ** SEE INSTRUCTIONS BEFORE FILLING OUT!






CUSIP No. 02216N105                 13G                  Page 4 of 13 Pages

-----------------------------------------------------------------------------
     (1)    NAMES OF REPORTING PERSONS
            I.R.S. IDENTIFICATION NO.
            OF ABOVE PERSONS (ENTITIES ONLY)
                                           Adage Capital Advisors, L.L.C.
-----------------------------------------------------------------------------
     (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP **
                                                                  (a)  [ ]
                                                                  (b)  [X]
-----------------------------------------------------------------------------
     (3)    SEC USE ONLY
-----------------------------------------------------------------------------
     (4)    CITIZENSHIP OR PLACE OF ORGANIZATION
                            Delaware
-----------------------------------------------------------------------------
NUMBER OF      (5)  SOLE VOTING POWER
                                                -0-
SHARES         --------------------------------------------------------------

BENEFICIALLY   (6)  SHARED VOTING POWER
                    Warrant to purchase 1,962,494 shares of Common Stock

                    112,506 shares of Common Stock
OWNED BY       --------------------------------------------------------------

EACH           (7)  SOLE DISPOSITIVE POWER
                                                -0-
REPORTING      --------------------------------------------------------------

PERSON WITH    (8)  SHARED DISPOSITIVE POWER
                    Warrant to purchase 1,962,494 shares of Common Stock

                    112,506 shares of Common Stock
-----------------------------------------------------------------------------
     (9)    AGGREGATE AMOUNT BENEFICIALLY OWNED
            BY EACH REPORTING PERSON
            Warrant to purchase 1,962,494 shares of Common Stock

            112,506 shares of Common Stock
-----------------------------------------------------------------------------
     (10)   CHECK BOX IF THE AGGREGATE AMOUNT
            IN ROW (9) EXCLUDES CERTAIN SHARES **                       [ ]
-----------------------------------------------------------------------------
     (11)   PERCENT OF CLASS REPRESENTED
            BY AMOUNT IN ROW (9)
                                                8.4%
-----------------------------------------------------------------------------
     (12)   TYPE OF REPORTING PERSON **
                                                 OO
-----------------------------------------------------------------------------
                     ** SEE INSTRUCTIONS BEFORE FILLING OUT!






CUSIP No. 02216N105                13G                   Page 5 of 13 Pages

-----------------------------------------------------------------------------
     (1)    NAMES OF REPORTING PERSONS
            I.R.S. IDENTIFICATION NO.
            OF ABOVE PERSONS (ENTITIES ONLY)
                                                   Robert Atchinson
-----------------------------------------------------------------------------
     (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP **
                                                                  (a)  [ ]
                                                                  (b)  [X]
-----------------------------------------------------------------------------
     (3)    SEC USE ONLY
-----------------------------------------------------------------------------
     (4)    CITIZENSHIP OR PLACE OF ORGANIZATION
                            United States
-----------------------------------------------------------------------------
NUMBER OF      (5)  SOLE VOTING POWER
                                                -0-
SHARES         --------------------------------------------------------------

BENEFICIALLY   (6)  SHARED VOTING POWER
                    Warrant to purchase 1,962,494 shares of Common Stock

                    112,506 shares of Common Stock
OWNED BY       --------------------------------------------------------------

EACH           (7)  SOLE DISPOSITIVE POWER
                                                -0-
REPORTING      --------------------------------------------------------------

PERSON WITH    (8)  SHARED DISPOSITIVE POWER
                    Warrant to purchase 1,962,494 shares of Common Stock

                    112,506 shares of Common Stock
-----------------------------------------------------------------------------
     (9)    AGGREGATE AMOUNT BENEFICIALLY OWNED
            BY EACH REPORTING PERSON
            Warrant to purchase 1,962,494 shares of Common Stock

            112,506 shares of Common Stock
-----------------------------------------------------------------------------
     (10)   CHECK BOX IF THE AGGREGATE AMOUNT
            IN ROW (9) EXCLUDES CERTAIN SHARES **                       [ ]
-----------------------------------------------------------------------------
     (11)   PERCENT OF CLASS REPRESENTED
            BY AMOUNT IN ROW (9)
                                                8.4%
-----------------------------------------------------------------------------
     (12)   TYPE OF REPORTING PERSON **
                                                 IN
-----------------------------------------------------------------------------
                     ** SEE INSTRUCTIONS BEFORE FILLING OUT!






CUSIP No. 02216N105                13G                   Page 6 of 13 Pages

-----------------------------------------------------------------------------
     (1)    NAMES OF REPORTING PERSONS
            I.R.S. IDENTIFICATION NO.
            OF ABOVE PERSONS (ENTITIES ONLY)
                                                    Phillip Gross
-----------------------------------------------------------------------------
     (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP **
                                                                  (a)  [ ]
                                                                  (b)  [X]
-----------------------------------------------------------------------------
     (3)    SEC USE ONLY
-----------------------------------------------------------------------------
     (4)    CITIZENSHIP OR PLACE OF ORGANIZATION
                            United States
-----------------------------------------------------------------------------
NUMBER OF      (5)  SOLE VOTING POWER
                                                -0-
SHARES         --------------------------------------------------------------

BENEFICIALLY   (6)  SHARED VOTING POWER
                    Warrant to purchase 1,962,494 shares of Common Stock

                    112,506 shares of Common Stock
OWNED BY       --------------------------------------------------------------

EACH           (7)  SOLE DISPOSITIVE POWER
                                                -0-
REPORTING      --------------------------------------------------------------

PERSON WITH    (8)  SHARED DISPOSITIVE POWER
                    Warrant to purchase 1,962,494 shares of Common Stock

                    112,506 shares of Common Stock
-----------------------------------------------------------------------------
     (9)    AGGREGATE AMOUNT BENEFICIALLY OWNED
            BY EACH REPORTING PERSON
            Warrant to purchase 1,962,494 shares of Common Stock

            112,506 shares of Common Stock
-----------------------------------------------------------------------------
     (10)   CHECK BOX IF THE AGGREGATE AMOUNT
            IN ROW (9) EXCLUDES CERTAIN SHARES **                       [ ]
-----------------------------------------------------------------------------
     (11)   PERCENT OF CLASS REPRESENTED
            BY AMOUNT IN ROW (9)
                                                8.4%
-----------------------------------------------------------------------------
     (12)   TYPE OF REPORTING PERSON **
                                                 IN
-----------------------------------------------------------------------------
                     ** SEE INSTRUCTIONS BEFORE FILLING OUT!






CUSIP No. 02216N105                13G                   Page 7 of 13 Pages

Item 1(a).     Name of Issuer:

     The name of the issuer is Altus Pharmaceuticals Inc. (the "Company").

Item 1(b).     Address of Issuer's Principal Executive Offices:

     The Company's principal executive offices are located at 125 Sidney
Street, Cambridge, MA PostalCode02139

Item 2(a).     Name of Person Filing:

     This statement is filed by:
          (i) Adage Capital Partners, L.P., a Delaware limited
              partnership ("ACP"), with respect to 112,506 shares of Common
              Stock and the Warrant to purchase 1,962,494 shares of Common
              Stock (the "Warrant") directly owned by it;
         (ii) Adage Capital Partners GP, L.L.C., a limited liability company
              organized under the laws of the State of Delaware
              ("ACPGP"), as general partner of ACP, with respect to the
              shares of Common Stock and the Warrant directly owned by
              ACP;
        (iii) Adage Capital Advisors, L.L.C., a limited liability company
              organized under the laws of the State of Delaware ("ACA"),
              as managing member of ACPGP, general partner of ACP, with
              respect to the shares of Common Stock and the Warrant
              directly owned by ACP;
         (iv) Phillip Gross ("Mr. Gross"), as managing member of ACA,
              managing member of ACPGP, general partner of ACP, with
              respect to the shares of Common Stock and the Warrant
              directly owned by ACP; and
          (v) Robert Atchinson ("Mr. Atchinson"), as managing member of
              ACA, managing member of ACPGP, general partner of ACP, with
              respect to the shares of Common Stock and the Warrant
              directly owned by ACP.

         The foregoing persons are hereinafter collectively referred to as
         the "Reporting Persons." Any disclosures herein with respect to
         persons other than the Reporting Persons are made on information
         and belief after making inquiry to the appropriate party.

Item 2(b).     Address of Principal Business Office or, if None, Residence:

     The address of the business office of each of the Reporting Persons is
200 Clarendon Street, 52nd Floor, Boston, Massachusetts 02116.

Item 2(c).     Citizenship:

     ACP is a limited partnership organized under the laws of the State of
Delaware.  ACPGP and ACA are limited liability companies organized under the
laws of the State of Delaware.  Messrs. Gross and Atchinson are citizens of the
United States.

Item 2(d).     Title of Class of Securities:

     Common Stock, $0.01 par value per share (the "Common Stock")






CUSIP No. 02216N105                13G                   Page 8 of 13 Pages

Item 2(e).  CUSIP Number:

     02216N105


Item 3. If this statement is filed pursuant to Rules 13d-1(b) or 13d-2(b) or
(c), check whether the person filing is a:

          (a) [ ]  Broker or dealer registered under Section 15 of the
                   Act,

          (b) [ ]  Bank as defined in Section 3(a)(6) of the Act,

          (c) [ ]  Insurance Company as defined in Section 3(a)(19) of
                   the Act,

          (d) [ ]  Investment Company registered under Section 8 of the
                   Investment Company Act of 1940,

          (e) [ ]  Investment Adviser in accordance with Rule
                   13d-1 (b)(1)(ii)(E),

          (f) [ ]  Employee Benefit Plan or Endowment Fund in accordance
                   with 13d-1 (b)(1)(ii)(F),

          (g) [ ]  Parent Holding Company or control person in accordance
                   with Rule 13d-1 (b)(1)(ii)(G),

          (h) [ ]  Savings Association as defined in Section 3(b) of the
                   Federal Deposit Insurance Act,

          (i) [ ]  Church Plan that is excluded from the definition of an
                   investment company under Section 3(c)(14) of the Investment
                   Company Act of 1940,

          (j) [ ]  Group, in accordance with Rule 13d-1(b)(1)(ii)(J).

     If this statement is filed pursuant to 13d-1(c), check this box:  [x]


Item 4.   Ownership.

      A.   Adage Capital Partners, L.P., Adage Capital Partners GP, L.L.C.
and Adage Capital Advisors, L.L.C.
                  (a) Amount beneficially owned:
                      Warrant to purchase 1,962,494 shares of Common Stock

                      112,506 shares of Common Stock

                  (b) Percent of class: 8.4%. According to information
                      provided to the Reporting Persons by the Company,
                      there are 22,674,735 shares of Common Stock issued and
                      outstanding as of September 30, 2006. The percentages
                      used herein and in the rest of Item 4 are calculated
                      based upon such information.





CUSIP No. 02216N105                 13G                  Page 9 of 13 Pages

                  (c)(i) Sole power to vote or direct the vote: -0-

                    (ii) Shared power to vote or direct the vote:
                         Warrant to purchase 1,962,494 shares of Common Stock

                         112,506 shares of Common Stock

                   (iii) Sole power to dispose or direct the disposition: -0-

                    (iv) Shared power to dispose or direct the disposition:
                         Warrant to purchase 1,962,494 shares of Common Stock

                         112,506 shares of Common Stock

                     ACP has the power to dispose of and the power to vote
                     the shares of Common Stock beneficially owned by it (in
                     the case of shares of Common Stock purchased upon
                     exercise of the Warrant or currently owned directly by
                     ACP), which power may be exercised by its general
                     partner, ACPGP. ACA, as managing member of ACPGP,
                     directs ACPGP's operations. Neither ACPGP nor ACA
                     directly owns the Warrant or any shares of Common Stock.
                     By reason of the provisions of Rule 13d-3 of the
                     Securities Exchange Act of 1934 (the "Act"), ACPGP and
                     ACA may be deemed to own beneficially the shares of
                     Common Stock beneficially owned by ACP.

      B.   Robert Atchinson and Phillip Gross
                (a) Amount beneficially owned:
                    Warrant to purchase 1,962,494 shares of Common Stock

                    112,506 shares of Common Stock

                (b) Percent of class: 8.4%

                (c)(i) Sole power to vote or direct the vote: -0-

                  (ii) Shared power to vote or direct the vote:
                       Warrant to purchase 1,962,494 shares of Common Stock

                       112,506 shares of Common Stock

                 (iii) Sole power to dispose or direct the disposition: -0-

                  (iv) Shared power to dispose or direct the disposition:

                       Warrant to purchase 1,962,494 shares of Common Stock

                       112,506 shares of Common Stock

                  Messrs. Atchinson and Gross, as managing members of ACA,
                  have shared power to vote the shares of Common Stock
                  beneficially owned by ACP (in the case of shares of
                  Common Stock purchased upon exercise of the Warrant or
                  currently owned directly by ACP). Neither Mr. Atchinson
                  nor Mr. Gross directly owns the Warrant or any shares of
                  Common Stock. By reason of the






CUSIP No. 02216N105                 13G                  Page 10 of 13 Pages

                  provisions of Rule 13d-3 of the Act, each may be deemed
                  to beneficially own the shares of Common Stock
                  beneficially owned by ACP.

Item 5.     Ownership of Five Percent or Less of a Class.

     Not applicable.


Item 6.     Ownership of More than Five Percent on Behalf of Another Person.

     ACPGP, the general partner of ACP, has the power to direct the affairs of
ACP, including decisions respecting the disposition of the proceeds from the
sale of the Warrant or any shares of Common Stock. Messrs. Atchinson and Gross
are the managing members of ACA, the managing member of ACPGP, and in that
capacity direct ACPGP's operations.

Item 7.     Identification and Classification of the Subsidiary Which Acquired
the Security Being Reported on by the Parent Holding Company.

     Not applicable.


Item 8.  Identification and Classification of Members of the Group.

     Not applicable.

Item 9.  Notice of Dissolution of Group.

     Not applicable.


Item 10. Certification.

     Each of the Reporting Persons hereby makes the following certification:

          By signing below each Reporting Person certifies that, to the best of
its knowledge and belief, the securities referred to above were not acquired and
are not held for the purpose of or with the effect of changing or influencing
the control of the issuer of the securities and were not acquired and are not
held in connection with or as a participant in any transaction having that
purpose or effect.






CUSIP No. 02216N105                 13G                 Page 11 of 13 Pages

                                   SIGNATURES

After reasonable inquiry and to the best of our knowledge and belief, the
undersigned certify that the information set forth in this statement is true,
complete and correct.


DATED:  October 18, 2006

                                    ADAGE CAPITAL PARTNERS, L.P.

                                    By: Adage Capital Partners GP, L.L.C.,
                                        its general partner
                                    By: Adage Capital Advisors, L.L.C.,
                                        its managing member

                                    /s/ Robert Atchinson
                                    --------------------
                                    Name:  Robert Atchinson
                                    Title: Managing Member


                                    ADAGE CAPITAL PARTNERS GP, L.L.C.
                                    By: Adage Capital Advisors, L.L.C.,
                                        its managing member

                                    /s/ Robert Atchinson
                                    --------------------
                                    Name:  Robert Atchinson
                                    Title: Managing Member


                                    ADAGE CAPITAL ADVISORS, L.L.C.

                                    /s/ Robert Atchinson
                                    --------------------
                                    Name:  Robert Atchinson
                                    Title: Managing Member


                                    ROBERT ATCHINSON

                                    /s/ Robert Atchinson
                                    --------------------
                                    ROBERT ATCHINSON, individually


                                    PHILLIP GROSS

                                    /s/ Phillip Gross
                                    -----------------
                                    PHILLIP GROSS, individually






CUSIP No. 02216N105                 13G                  Page 12 of 13 Pages

                                    EXHIBIT 1

                           JOINT ACQUISITION STATEMENT

                            PURSUANT TO RULE 13d-1(k)

          The undersigned acknowledge and agree that the foregoing statement on
Schedule 13G, is filed on behalf of each of the undersigned and that all
subsequent amendments to this statement on Schedule 13G, shall be filed on
behalf of each of the undersigned without the necessity of filing additional
joint acquisition statements. The undersigned acknowledge that each shall be
responsible for the timely filing of such amendments, and for the completeness
and accuracy of the information concerning him or it contained therein, but
shall not be responsible for the completeness and accuracy of the information
concerning the others, except to the extent that he or it knows or has reason to
believe that such information is inaccurate.



DATED:  October 18, 2006       ADAGE CAPITAL PARTNERS, L.P.
                                By:  Adage Capital Partners GP, L.L.C.,
                                     its general partner
                                By:  Adage Capital Advisors, L.L.C.,
                                     its managing member

                                /s/ Robert Atchinson
                                ------------------------------
                                Name:  Robert Atchinson
                                Title: Managing Member


                                ADAGE CAPITAL PARTNERS GP, L.L.C.
                                By:  Adage Capital Advisors, L.L.C.,
                                     its managing member

                                /s/ Robert Atchinson
                                ------------------------------
                                Name:  Robert Atchinson
                                Title: Managing Member


                                ADAGE CAPITAL ADVISORS, L.L.C.

                                /s/ Robert Atchinson
                                ------------------------------
                                Name:  Robert Atchinson
                                Title: Managing Member


                                ROBERT ATCHINSON

                                /s/ Robert Atchinson
                                ------------------------------
                                Name:  Robert Atchinson






CUSIP No. 02216N105                 13G                  Page 13 of 13 Pages

                                PHILLIP GROSS

                                /s/ Phillip Gross
                                ------------------------------
                                Name:  Phillip Gross