14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant [ X ] Filed by a Party other than the Registrant [ ] Check the appropriate box: [ ] Preliminary Proxy Statement [ ] Confidential, for Use of the Commission Only (as Permitted by Rule 14a-6(e)(2)) [ ] Definitive Proxy Statement [ X ] Definitive Additional Materials [ ] Solicitation Material Pursuant to Rule 14a-11(c) or rule 14a-12 Hemispherx Biopharma, Inc. ________________________________________________ (Name of Registrant as Specified in its Charter) (Name of Person(s) Filing Proxy Statement, if Other Than the Registrant) Payment of Filing Fee (Check the appropriate box): [x] No fee required. [ ] Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11. Title of each class of securities to which transaction applies: Aggregate number of securities to which transaction applies: Per unit price or other underlying value of transaction computed pursuant to Exchange Act Rule 0-11: Proposed maximum aggregate value of transaction: ---------------------- 5) Total fee paid: ------------------- [ ] Fee paid previously with preliminary materials. [ ] Check box if any part of the fee is offset as provided by Exchange Act Rule 0-11(a)(2) and identify the filing for which the offsetting fee was paid previously. Identify the previous filing by registration statement number, or the Form or Schedule and the date of its filing. (1) Amount Previously Paid: (2) Form, Schedule or Registration Statement No.: --------------------- (3) Filing Party: (4) Date Filed: Dear Stockholders of Hemispherx Biopharma, It is extremely important that you vote your shares for the annual stockholder meeting. If you have already voted, thank you for your participation. If you have not, I strongly urge you to vote your proxy as soon as possible. The record date remains July 21, 2008. The purposes for which the meeting is being held remain the same as those listed in our Notice of Annual Meeting of August 1, 2008. United States stockholders will receive an additional proxy mailing electronically or in the mail. The following information is for European stockholders of Hemispherx: A significant number of stockholders are domiciled in Europe and less readily accessible for notification purposes. European banks do not forward the proxy to European stockholders, and will need to contact your bank directly. The following banks will vote directly on behalf of the stockholder as instructed: KBC - Contact Nadine Merckx at +32 2 429 2549 or e mail general.meetings@kbcsecurities.be ATTN: Nadine Merckx in the subject line. Dexia - Contact K. Nelis at +32 2 222 11 11 Fortis: Contact Kellen Van Liefferinge at +32 (0)2 210 42 52 or Tarik Daggouz at +32 22748384 All others banks will issue a legal proxy or a certificate certifying the number of shares owned, which must be accompanied by a signed and dated proxy. The following is contact information to request a legal proxy or certificate: Keytrade: Mr. Condotta at +32 2 679 9119 or email paolo.condotta@keytradebank.com Procapital Belgium: Jo Cuyvers at +32 2.505.01.60 or email jo.cuyvers@procapital.be ING: Sonia De Block at +32 2 738 21 21 or e mail sonia.de-block@ing.be Please send a copy of the certificate accompanied by a signed and dated proxy card as soon as possible via fax or e mail to: Fax: +001 212 929 0308 e-mail: proxy@mackenziepartners.com or dwil@willstar.net If your bank is not listed above, please contact me and I will assist you in obtaining information on how to vote your shares. Best regards, Dianne Will Investor Relations for Hemispherx Biopharma, Inc. Dianne Will Investor Relations phone: 518-398-6222 e-mail: dwill@willstar.net This communication and any files transmitted with it contain information that is confidential and may be privileged and exempt from disclosure under applicable law. It is intended solely for the use of the individual or entity to which it is addressed. If you are not the intended recipient, you are hereby notified that any use, dissemination or copying of this communication is strictly prohibited. If you have received this communication in error, please notify the sender. Thank you for your cooperation.