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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
SCHEDULE 13G/A
Under the Securities Exchange Act of 1934
(AMENDMENT NO     5     )*
METABASIS THERAPEUTICS, INC
(Name of Issuer)
Common Stock
(Title of Class of Securities)
59101M 10 5
(CUSIP Number)
December 31, 2008
(Date of Event which Requires Filing of this Statement)
Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
o Rule 13d-1(b)
o Rule 13d-1(c)
þ Rule 13d-1(d)
*The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.
The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).
 
 

Page 1 of 16 Pages

 

                     
CUSIP No.
  
59101M 10 5 
 13G   Page
2 
   of   
16 Pages 

 

           
1   NAME OF REPORTING PERSONS
InterWest Partners VII, LP
I.R.S. IDENTIFICATION NO(S). OF ABOVE PERSON(S) (ENTITIES ONLY)
     
     
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

  (a)   o
  (b)   o
     
3   SEC USE ONLY
   
   
     
4   CITIZENSHIP OR PLACE OF ORGANIZATION
   
  California
       
  5   SOLE VOTING POWER
     
NUMBER OF   4,029,455
       
SHARES 6   SHARED VOTING POWER
BENEFICIALLY    
OWNED BY   0
       
REPORTING 7   SOLE DISPOSITIVE POWER
PERSON    
WITH   4,029,455
       
8   SHARED DISPOSITIVE POWER
     
    0
     
9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
   
  4,029,455
     
10   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES:
   
  o
     
11   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
   
  11.4%
     
12   TYPE OF REPORTING PERSON
   
  PN

 

 

                     
CUSIP No.
  
59101M 10 5 
 13G Page  
3 
   of   
16 Pages 

 

           
1   NAME OF REPORTING PERSONS
InterWest Investors VII, LP
I.R.S. IDENTIFICATION NO(S). OF ABOVE PERSON(S) (ENTITIES ONLY)
     
     
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

  (a)   o
  (b)   o
     
3   SEC USE ONLY
   
   
     
4   CITIZENSHIP OR PLACE OF ORGANIZATION
   
  California
       
  5   SOLE VOTING POWER
     
NUMBER OF   192,907
       
SHARES 6   SHARED VOTING POWER
BENEFICIALLY    
OWNED BY   0
       
REPORTING 7   SOLE DISPOSITIVE POWER
PERSON    
WITH   192,907
       
8   SHARED DISPOSITIVE POWER
     
    0
     
9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
   
  192,907
     
10   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES:
   
  o
     
11   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
   
  0.55%
     
12   TYPE OF REPORTING PERSON
   
  PN

 

 

                     
CUSIP No.
  
59101M 10 5 
 13G Page  
4 
   of   
16 Pages 

 

           
1   NAME OF REPORTING PERSONS
InterWest Management Partners VII, LLC (the General Partner of InterWest Partners VII, LP and InterWest Investors VII, LP)
I.R.S. IDENTIFICATION NO(S). OF ABOVE PERSON(S) (ENTITIES ONLY)
     
     
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

  (a)   o
  (b)   o
     
3   SEC USE ONLY
   
   
     
4   CITIZENSHIP OR PLACE OF ORGANIZATION
   
  California
       
  5   SOLE VOTING POWER
     
NUMBER OF   4,222,362
       
SHARES 6   SHARED VOTING POWER
BENEFICIALLY    
OWNED BY   0
       
REPORTING 7   SOLE DISPOSITIVE POWER
PERSON    
WITH   4,222,362
       
8   SHARED DISPOSITIVE POWER
     
    0
     
9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
   
  4,222,362
     
10   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES:
   
  o
     
11   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
   
  11.9%
     
12   TYPE OF REPORTING PERSON
   
  OO

 

 

                     
CUSIP No.
  
59101M 10 5 
 13G Page  
5 
   of   
16 Pages 

 

           
1   NAME OF REPORTING PERSONS
Harvey B. Cash (a Managing Director of InterWest Management Partners VII, LLC)
I.R.S. IDENTIFICATION NO(S). OF ABOVE PERSON(S) (ENTITIES ONLY)
     
     
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

  (a)   o
  (b)   o
     
3   SEC USE ONLY
   
   
     
4   CITIZENSHIP OR PLACE OF ORGANIZATION
   
  United States
       
  5   SOLE VOTING POWER
     
NUMBER OF   50,000
       
SHARES 6   SHARED VOTING POWER
BENEFICIALLY    
OWNED BY   4,222,362
       
REPORTING 7   SOLE DISPOSITIVE POWER
PERSON    
WITH   50,000
       
8   SHARED DISPOSITIVE POWER
     
    4,222,362
     
9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
   
  4,272,362
     
10   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES:
   
  o
     
11   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
   
  12.1%
     
12   TYPE OF REPORTING PERSON
   
  IN
Neither the filing of this statement on Schedule 13G nor any of its contents shall be deemed to constitute an admission by Harvey B. Cash that he is the beneficial owner of any of the Common Stock referred to herein for purposes of Section 13(d) of the Securities Exchange Act of 1934, as amended, or for any other purpose, and such beneficial ownership is expressly disclaimed, except to the extent of his pecuniary interest.

 

 

                     
CUSIP No.
  
59101M 10 5 
 13G Page  
6 
   of   
16 Pages 

 

           
1   NAME OF REPORTING PERSONS
Philip T. Gianos (a Managing Director of InterWest Management Partners VII, LLC)
I.R.S. IDENTIFICATION NO(S). OF ABOVE PERSON(S) (ENTITIES ONLY)
     
     
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

  (a)   o
  (b)   o
     
3   SEC USE ONLY
   
   
     
4   CITIZENSHIP OR PLACE OF ORGANIZATION
   
  United States
       
  5   SOLE VOTING POWER
     
NUMBER OF   0
       
SHARES 6   SHARED VOTING POWER
BENEFICIALLY    
OWNED BY   4,222,362
       
REPORTING 7   SOLE DISPOSITIVE POWER
PERSON    
WITH   0
       
8   SHARED DISPOSITIVE POWER
     
    4,222,362
     
9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
   
  4,222,362
     
10   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES:
   
  o
     
11   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
   
  11.9%
     
12   TYPE OF REPORTING PERSON
   
  IN
Neither the filing of this statement on Schedule 13G nor any of its contents shall be deemed to constitute an admission by Philip T. Gianos that he is the beneficial owner of any of the Common Stock referred to herein for purposes of Section 13(d) of the Securities Exchange Act of 1934, as amended, or for any other purpose, and such beneficial ownership is expressly disclaimed, except to the extent of his pecuniary interest.

 

 

                     
CUSIP No.
  
59101M 10 5 
 13G Page  
7 
   of   
16 Pages 

 

           
1   NAME OF REPORTING PERSONS
W. Scott Hedrick (a Managing Director of InterWest Management Partners VII, LLC)
I.R.S. IDENTIFICATION NO(S). OF ABOVE PERSON(S) (ENTITIES ONLY)
     
     
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

  (a)   o
  (b)   o
     
3   SEC USE ONLY
   
   
     
4   CITIZENSHIP OR PLACE OF ORGANIZATION
   
  United States
       
  5   SOLE VOTING POWER
     
NUMBER OF   0
       
SHARES 6   SHARED VOTING POWER
BENEFICIALLY    
OWNED BY   4,222,362
       
REPORTING 7   SOLE DISPOSITIVE POWER
PERSON    
WITH   0
       
8   SHARED DISPOSITIVE POWER
     
    4,222,362
     
9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
   
  4,222,362
     
10   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES:
   
  o
     
11   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
   
  11.9%
     
12   TYPE OF REPORTING PERSON
   
  IN
Neither the filing of this statement on Schedule 13G nor any of its contents shall be deemed to constitute an admission by W. Scott Hedrick that he is the beneficial owner of any of the Common Stock referred to herein for purposes of Section 13(d) of the Securities Exchange Act of 1934, as amended, or for any other purpose, and such beneficial ownership is expressly disclaimed, except to the extent of his pecuniary interest.

 

 

                     
CUSIP No.
  
59101M 10 5 
 13G Page  
8 
   of   
16 Pages 

 

           
1   NAME OF REPORTING PERSONS
W. Stephen Holmes III (a Managing Director of InterWest Management Partners VII, LLC)
I.R.S. IDENTIFICATION NO(S). OF ABOVE PERSON(S) (ENTITIES ONLY)
     
     
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

  (a)   o
  (b)   o
     
3   SEC USE ONLY
   
   
     
4   CITIZENSHIP OR PLACE OF ORGANIZATION
   
  United States
       
  5   SOLE VOTING POWER
     
NUMBER OF   0
       
SHARES 6   SHARED VOTING POWER
BENEFICIALLY    
OWNED BY   4,222,362
       
REPORTING 7   SOLE DISPOSITIVE POWER
PERSON    
WITH   0
       
8   SHARED DISPOSITIVE POWER
     
    4,222,362
     
9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
   
  4,222,362
     
10   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES:
   
  o
     
11   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
   
  11.9%
     
12   TYPE OF REPORTING PERSON
   
  IN
Neither the filing of this statement on Schedule 13G nor any of its contents shall be deemed to constitute an admission by W. Stephen Holmes III that he is the beneficial owner of any of the Common Stock referred to herein for purposes of Section 13(d) of the Securities Exchange Act of 1934, as amended, or for any other purpose, and such beneficial ownership is expressly disclaimed, except to the extent of his pecuniary interest.

 

 

                     
CUSIP No.
  
59101M 10 5  
 13G Page  
9 
   of   
16 Pages 

 

           
1   NAME OF REPORTING PERSONS
Gilbert H. Kliman (a Managing Director of InterWest Management Partners VII, LLC)
I.R.S. IDENTIFICATION NO(S). OF ABOVE PERSON(S) (ENTITIES ONLY)
     
     
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

  (a)   o
  (b)   o
     
3   SEC USE ONLY
   
   
     
4   CITIZENSHIP OR PLACE OF ORGANIZATION
   
  United States
       
  5   SOLE VOTING POWER
     
NUMBER OF   0
       
SHARES 6   SHARED VOTING POWER
BENEFICIALLY    
OWNED BY   4,222,362
       
REPORTING 7   SOLE DISPOSITIVE POWER
PERSON    
WITH   0
       
8   SHARED DISPOSITIVE POWER
     
    4,222,362
     
9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
   
  4,222,362
     
10   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES:
   
  o
     
11   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
   
  11.9%
     
12   TYPE OF REPORTING PERSON
   
  IN
Neither the filing of this statement on Schedule 13G nor any of its contents shall be deemed to constitute an admission by Gilbert H. Kliman that he is the beneficial owner of any of the Common Stock referred to herein for purposes of Section 13(d) of the Securities Exchange Act of 1934, as amended, or for any other purpose, and such beneficial ownership is expressly disclaimed, except to the extent of his pecuniary interest.

 

 

                     
CUSIP No.
  
59101M 10 5 
 13G Page  
10 
   of   
16 Pages 

 

           
1   NAME OF REPORTING PERSONS
Arnold L. Oronsky (a Managing Director of InterWest Management Partners VII, LLC)
I.R.S. IDENTIFICATION NO(S). OF ABOVE PERSON(S) (ENTITIES ONLY)
     
     
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

  (a)   o
  (b)   o
     
3   SEC USE ONLY
   
   
     
4   CITIZENSHIP OR PLACE OF ORGANIZATION
   
  United States
       
  5   SOLE VOTING POWER
     
NUMBER OF   56,667
       
SHARES 6   SHARED VOTING POWER
BENEFICIALLY    
OWNED BY   4,222,362
       
REPORTING 7   SOLE DISPOSITIVE POWER
PERSON    
WITH   56,667
       
8   SHARED DISPOSITIVE POWER
     
    4,222,362
     
9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
   
  4,279,029
     
10   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES:
   
  o
     
11   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
   
  12.1%
     
12   TYPE OF REPORTING PERSON
   
  IN
Neither the filing of this statement on Schedule 13G nor any of its contents shall be deemed to constitute an admission by Arnold L. Oronsky that he is the beneficial owner of any of the Common Stock referred to herein for purposes of Section 13(d) of the Securities Exchange Act of 1934, as amended, or for any other purpose, and such beneficial ownership is expressly disclaimed, except to the extent of his pecuniary interest.

 

 

                     
CUSIP No.
  
59101M 10 5 
 13G Page  
11 
   of   
16 Pages 

 

           
1   NAME OF REPORTING PERSONS
Thomas L. Rosch (a Managing Director of InterWest Management Partners VII, LLC)
I.R.S. IDENTIFICATION NO(S). OF ABOVE PERSON(S) (ENTITIES ONLY)
     
     
2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

  (a)   o
  (b)   o
     
3   SEC USE ONLY
   
   
     
4   CITIZENSHIP OR PLACE OF ORGANIZATION
   
  United States
       
  5   SOLE VOTING POWER
     
NUMBER OF   0
       
SHARES 6   SHARED VOTING POWER
BENEFICIALLY    
OWNED BY   4,222,362
       
REPORTING 7   SOLE DISPOSITIVE POWER
PERSON    
WITH   0
       
8   SHARED DISPOSITIVE POWER
     
    4,222,362
     
9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
   
  4,222,362
     
10   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES:
   
  o
     
11   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
   
  11.9%
     
12   TYPE OF REPORTING PERSON
   
  IN
Neither the filing of this statement on Schedule 13G nor any of its contents shall be deemed to constitute an admission by Thomas L. Rosch that he is the beneficial owner of any of the Common Stock referred to herein for purposes of Section 13(d) of the Securities Exchange Act of 1934, as amended, or for any other purpose, and such beneficial ownership is expressly disclaimed, except to the extent of his pecuniary interest.

 

 

ITEM 1.
(a)   NAME OF ISSUER: Metabasis Therapeutics, Inc.
 
(b)   ADDRESS OF ISSUER’S PRINCIPAL EXECUTIVE OFFICE:
 
    11119 North Torrey Pines Road, La Jolla, CA 92037
ITEM 2.
(a)   NAME OF PERSON(S) FILING:
 
    InterWest Partners VII, LP (“IWP VII”)
InterWest Investors VII, LP (“II VII”)
InterWest Management Partners VII, LLC (“IMP VII”)
Harvey B. Cash (“Cash”)
Philip T. Gianos (“Gianos”)
W. Scott Hedrick (“Hedrick”)
W. Stephen Holmes III (“Holmes”)
Gilbert H. Kliman (“Kliman”)
Arnold L. Oronsky (“Oronsky”)
Thomas L. Rosch (“Rosch”)
(b)   ADDRESS OF PRINCIPAL BUSINESS OFFICE OR, IF NONE, RESIDENCE:
 
    2710 Sand Hill Road, Second Floor, Menlo Park, CA 94025
(c)   CITIZENSHIP/PLACE OF ORGANIZATION:
         
 
IWP VII:   California
 
II VII:   California
 
IMP VII:   California
 
Cash:   United States
 
Gianos:   United States
 
Hedrick:   United States
 
Holmes:   United States
 
Kliman:   United States
 
Oronsky:   United States
 
Rosch:   United States
Page 12 of 16 Pages

 

 

(d)   TITLE OF CLASS OF SECURITIES:       Common Stock
 
(e)   CUSIP NUMBER:      59101M 10 5
ITEM 3. NOT APPLICABLE.
ITEM 4. OWNERSHIP.
                         
    IWP VII (1)   II VII (2)   IMP VII (3)
Beneficial Ownership
     4,029,455       192,907       4,222,362  
Percentage of Class
     11.4 %     0.55 %     11.9 %
Sole Voting Power
     4,029,455       192,907       4,222,362  
Shared Voting Power
     0       0       0  
Sole Dispositive Power
     4,029,455       192,907       4,222,362  
Shared Dispositive Power
     0       0       0  
                         
    Cash (4)   Gianos (4)   Hedrick (4)
Beneficial Ownership
     4,272,362       4,222,362       4,222,362  
Percentage of Class
     12.1 %     11.9 %     11.9 %
Sole Voting Power
     50,000       0       0  
Shared Voting Power
     4,222,362       4,222,362       4,222,362  
Sole Dispositive Power
     50,000       0       0  
Shared Dispositive Power
     4,222,362       4,222,362       4,222,362  
                                 
    Holmes (4)   Kliman (4)   Oronsky (4)**   Rosch (4)
Beneficial Ownership
     4,222,362       4,222,362       4,279,029       4,222,362  
Percentage of Class
     11.9 %     11.9 %     12.1 %     11.9 %
Sole Voting Power
     0       0       56,667       0  
Shared Voting Power
     4,222,362       4,222,362       4,222,362       4,222,362  
Sole Dispositive Power
     0       0       56,667       0  
Shared Dispositive Power
     4,222,362       4,222,362       4,222,362       4,222,362  
 
**   Includes 56,667 shares issuable to Oronsky pursuant to outstanding options exercisable within 60 days of December 31, 2008.
 
(1)   Includes 312,173 shares issuable pursuant to warrant exercise after October 16, 2008.
 
(2)   Includes 14,937 shares issuable pursuant to warrant exercise after October 16, 2008.
 
(3)   IMP VII is the general partner of IWP VII and II VII.
 
(4)   Cash, Gianos, Hedrick, Holmes, Kliman, Oronsky, and Rosch are Managing Directors of IMP VII.
Page 13 of 16 Pages

 

 

ITEM 5. OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS.
Not applicable.
ITEM 6. OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON.
Under certain circumstances set forth in the limited liability company operating agreement of IMP VII, the members of such limited liability company have the right to receive dividends from, or the proceeds from the sale of, the common stock of Issuer beneficially owned by such limited liability company.
ITEM 7. IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY.
Not applicable.
ITEM 8. IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP.
No reporting person is a member of a group as defined in section 240.13d-1(b)(1)(iii)(H) of the Act.
ITEM 9. NOTICE OF DISSOLUTION OF THE GROUP.
Not applicable.
ITEM 10. CERTIFICATION.
Not applicable.
EXHIBITS
Joint Filing Statement attached as Exhibit A.
Page 14 of 16 Pages

 

 

SIGNATURE
After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.
Date: February 13, 2009
                 
        INTERWEST PARTNERS VII, LP    
 
                
By:  /s/ Harvey B. Cash
 
Name:  Harvey B. Cash
      By:   InterWest Management Partners VII, LLC
its General Partner		    
 
                
By:  /s/ Philip T. Gianos
 
Name:  Philip T. Gianos
          By:  /s/ W. Stephen Holmes
 
        Managing Director  		   
 
                
By:  /s/ W. Scott Hedrick
 
       INTERWEST INVESTORS VII, LP    
Name:  W. Scott Hedrick
             
By:  /s/ W. Stephen Holmes
 
       By:   InterWest Management Partners VII, LLC
its General Partner		  
Name:  W. Stephen Holmes III
             
            By:   /s/ W. Stephen Holmes
 
    
By:/s/ Gilbert H. Kliman
 
                   Managing Director     
Name: Gilbert H. Kliman
             
      INTERWEST MANAGEMENT PARTNERS VII, LLC    
By:  /s/ Arnold L. Oronsky
 
                
Name:  Arnold L. Oronsky
      By:   /s/ W. Stephen Holmes    
         
 
Managing Director 		   
By:  /s/ Thomas L. Rosch
 
                
Name:  Thomas L. Rosch
                
Page 15 of 16 Pages

 

 

EXHIBIT A
Joint Filing Statement
We, the undersigned, hereby express our agreement that the attached Schedule 13G is filed on behalf of each of us.
Date: February 13, 2009
                 
        INTERWEST PARTNERS VII, LP    
 
                
By:  /s/ Harvey B. Cash
 
Name:  Harvey B. Cash
      By:   InterWest Management Partners VII, LLC
its General Partner		    
 
                
By:  /s/ Philip T. Gianos
 
Name:  Philip T. Gianos
          By:  /s/ W. Stephen Holmes
 
        Managing Director  		   
 
By:  /s/ W. Scott Hedrick
 
Name:  W. Scott Hedrick
      INTERWEST INVESTORS VII, LP    
 
                
 
       By:    InterWest Management Partners VII, LLC its General Partner    
 
                
By:  /s/ W. Stephen Holmes
 
Name:  W. Stephen Holmes III
          By:  /s/ W. Stephen Holmes
 
        Managing Director  		   
 
                
By:  /s/ Gilbert H. Kliman
 
Name:  Gilbert H. Kliman
          By:  /s/ W. Stephen Holmes
 
        Managing Director  		   
 
                
By:  /s/ Arnold L. Oronsky
 
Name:  Arnold L. Oronsky
      INTERWEST MANAGEMENT PARTNERS VII, LLC    
                 
By:  /s/ Thomas L. Rosch
 
Name:  Thomas L. Rosch
      By:   /s/ W. Stephen Holmes
 
Managing Director 		   
                 
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