FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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(Print or Type Responses)

1. Name and Address of Reporting Person *   Lewis Mark L 2. Date of Event Requiring Statement (Month/Day/Year) 10/25/2012 3. Issuer Name and Ticker or Trading Symbol ILLUMINA INC [ILMN] (Last) (First) (Middle) 5200 ILLUMINA WAY 4. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director _____ 10% Owner __X__ Officer (give title below) _____ Other (specify below) Sr VP & GM Molecular Biology 5. If Amendment, Date Original Filed(Month/Day/Year) (Street) SAN DIEGO, CA 92122 6. Individual or Joint/Group Filing(Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Beneficially Owned

1.Title of Security (Instr. 4) 2. Amount of Securities Beneficially Owned (Instr. 4) 3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 4. Nature of Indirect Beneficial Ownership (Instr. 5) Common Stock 41,885 (1) D Â

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.			SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Non-Qualified Stock Option (right to buy)	12/15/2009(2)	12/15/2018	Common Stock	13,000	$ 21.37	D	Â
Non-Qualified Stock Option (right to buy)	02/27/2010(3)	01/27/2020	Common Stock	49,000	$ 37.04	D	Â
Non-Qualified Stock Option (right to buy)	02/28/2011(3)	01/31/2021	Common Stock	37,500	$ 69.34	D	Â

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
Lewis Mark L 5200 ILLUMINA WAY SAN DIEGO, CA 92122	Â	Â	  Sr VP & GM Molecular Biology	Â

Signatures

By: Scott M. Davies For: Mark L. Lewis		11/20/2012
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 5(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	Includes 17,791 unvested restricted stock units which vest as follows: 2,250 shares vest on 1/27/13; 833 shares vest on 1/31/13; 3,594 shares vest on 3/8/13; 2,625 shares vest on 1/27/14; 1,250 shares vest on 1/31/14; 3,594 shares vest on 3/8/14; 1,458 shares vest on 1/31/15; 1,094 shares vest on 3/8/15; 1,093 shares vest on 3/8/16; and 19,688 unvested performance stock units, which represent contingent right to receive one share of common stock based on the Company's earnings per share for fiscal year ending 12/28/14. Number of shares issued will range from 50% to 150% of 19,688 performance stock units, based on Company's actual earnings per share for fiscal year ending 12/28/14 relative to pre-defined objectives.
(2)	One-fourth (1/4) of the shares subject to the option become exercisable on the date indicated above, subject to optionee's continuing to be a service provider on such date. An additional one-forty eighth (1/48) of the shares subject to the option shall become exercisable each full month therafter, subject to optionee's continuing to be a service provider on such date.
(3)	One forty-eighth (1/48) of the Shares subject to the Option become exercisable on the date indicated above, subject to Optionee's continuing to be a Service Provider on such date. An additional one-forty eighth (1/48) of the Shares subject to the Option shall become exercisable each full month therafter, subject to Optionee's continuing to be a Service Provider on such date.

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