SECURITIES & EXCHANGE COMMISSION
                             Washington, D.C. 20549
                             ----------------------

                                  SCHEDULE 13G*
                                 (Rule 13d-102)

             INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT
           TO RULES 13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED
                              PURSUANT TO 13d-2(b)


                          Alexion Pharmaceuticals, Inc.
                                (Name of Issuer)

                         Common Stock, par value $0.0001
                         (Title of Class of Securities)

                                    015351109
                                 (CUSIP Number)

                                 March 26, 2007
             (Date of event which requires filing of this statement)


     Check the appropriate box to designate the rule pursuant to which this
Schedule 13G is filed:
     [ ]  Rule 13d-1(b)
     [X]  Rule 13d-1(c)
     [ ]  Rule 13d-1(d)





                              (Page 1 of 11 Pages)
----------------
     *The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would
alter the disclosures provided in a prior cover page.

     The information required in the remainder of this cover page shall not be
deemed to be "filed" for purposes of Section 18 of the Securities Exchange Act
of 1934 ("Act") or otherwise subject to the liabilities of that section of the
Act but shall be subject to all other provisions of the Act (however, see the
Notes).






CUSIP No.  015351109                 13G                  Page 2 of 11 Pages

-----------------------------------------------------------------------------
     (1)    NAMES OF REPORTING PERSONS
            I.R.S. IDENTIFICATION NO.
            OF ABOVE PERSONS (ENTITIES ONLY)
                                           Adage Capital Partners, L.P.
-----------------------------------------------------------------------------
     (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP **
                                                                  (a)  [ ]
                                                                  (b)  [X]
-----------------------------------------------------------------------------
     (3)    SEC USE ONLY
-----------------------------------------------------------------------------
     (4)    CITIZENSHIP OR PLACE OF ORGANIZATION
                            Delaware
-----------------------------------------------------------------------------
NUMBER OF      (5)  SOLE VOTING POWER
                                                -0-
SHARES         ______________________________________________________________

BENEFICIALLY   (6)  SHARED VOTING POWER
                                                1,966,200
OWNED BY       ______________________________________________________________

EACH           (7)  SOLE DISPOSITIVE POWER
                                                -0-
REPORTING      ______________________________________________________________

PERSON WITH    (8)  SHARED DISPOSITIVE POWER
                                                1,966,200
-----------------------------------------------------------------------------
     (9)    AGGREGATE AMOUNT BENEFICIALLY OWNED
            BY EACH REPORTING PERSON
                                                1,966,200
-----------------------------------------------------------------------------
     (10)   CHECK BOX IF THE AGGREGATE AMOUNT
            IN ROW (9) EXCLUDES CERTAIN SHARES **                       [ ]
-----------------------------------------------------------------------------
     (11)   PERCENT OF CLASS REPRESENTED
            BY AMOUNT IN ROW (9)
                                                5.5%
-----------------------------------------------------------------------------
     (12)   TYPE OF REPORTING PERSON **
                                                PN
-----------------------------------------------------------------------------
                     ** SEE INSTRUCTIONS BEFORE FILLING OUT!






CUSIP No.  015351109                 13G                  Page 3 of 11 Pages

-----------------------------------------------------------------------------
     (1)    NAMES OF REPORTING PERSONS
            I.R.S. IDENTIFICATION NO.
            OF ABOVE PERSONS (ENTITIES ONLY)
                                           Adage Capital Partners GP, L.L.C.
-----------------------------------------------------------------------------
     (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP **
                                                                  (a)  [ ]
                                                                  (b)  [X]
-----------------------------------------------------------------------------
     (3)    SEC USE ONLY
-----------------------------------------------------------------------------
     (4)    CITIZENSHIP OR PLACE OF ORGANIZATION
                            Delaware
-----------------------------------------------------------------------------
NUMBER OF      (5)  SOLE VOTING POWER
                                                -0-
SHARES         ______________________________________________________________

BENEFICIALLY   (6)  SHARED VOTING POWER
                                                1,966,200
OWNED BY       ______________________________________________________________

EACH           (7)  SOLE DISPOSITIVE POWER
                                                -0-
REPORTING      ______________________________________________________________

PERSON WITH    (8)  SHARED DISPOSITIVE POWER
                                                1,966,200
-----------------------------------------------------------------------------
     (9)    AGGREGATE AMOUNT BENEFICIALLY OWNED
            BY EACH REPORTING PERSON
                                                1,966,200
-----------------------------------------------------------------------------
     (10)   CHECK BOX IF THE AGGREGATE AMOUNT
            IN ROW (9) EXCLUDES CERTAIN SHARES **                       [ ]
-----------------------------------------------------------------------------
     (11)   PERCENT OF CLASS REPRESENTED
            BY AMOUNT IN ROW (9)
                                                5.5%
-----------------------------------------------------------------------------
     (12)   TYPE OF REPORTING PERSON **
                                                OO
-----------------------------------------------------------------------------
                     ** SEE INSTRUCTIONS BEFORE FILLING OUT!






CUSIP No.  015351109                 13G                  Page 4 of 11 Pages

-----------------------------------------------------------------------------
     (1)    NAMES OF REPORTING PERSONS
            I.R.S. IDENTIFICATION NO.
            OF ABOVE PERSONS (ENTITIES ONLY)
                                           Adage Capital Advisors, L.L.C.
-----------------------------------------------------------------------------
     (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP **
                                                                  (a)  [ ]
                                                                  (b)  [X]
-----------------------------------------------------------------------------
     (3)    SEC USE ONLY
-----------------------------------------------------------------------------
     (4)    CITIZENSHIP OR PLACE OF ORGANIZATION
                            Delaware
-----------------------------------------------------------------------------
NUMBER OF      (5)  SOLE VOTING POWER
                                                -0-
SHARES         ______________________________________________________________

BENEFICIALLY   (6)  SHARED VOTING POWER
                                                1,966,200
OWNED BY       ______________________________________________________________

EACH           (7)  SOLE DISPOSITIVE POWER
                                                -0-
REPORTING      ______________________________________________________________

PERSON WITH    (8)  SHARED DISPOSITIVE POWER
                                                1,966,200
-----------------------------------------------------------------------------
     (9)    AGGREGATE AMOUNT BENEFICIALLY OWNED
            BY EACH REPORTING PERSON
                                                1,966,200
-----------------------------------------------------------------------------
     (10)   CHECK BOX IF THE AGGREGATE AMOUNT
            IN ROW (9) EXCLUDES CERTAIN SHARES **                       [ ]
-----------------------------------------------------------------------------
     (11)   PERCENT OF CLASS REPRESENTED
            BY AMOUNT IN ROW (9)
                                                5.5%
-----------------------------------------------------------------------------
     (12)   TYPE OF REPORTING PERSON **
                                                OO
-----------------------------------------------------------------------------
                     ** SEE INSTRUCTIONS BEFORE FILLING OUT!






CUSIP No.  015351109                 13G                  Page 5 of 11 Pages

-----------------------------------------------------------------------------
     (1)    NAMES OF REPORTING PERSONS
            I.R.S. IDENTIFICATION NO.
            OF ABOVE PERSONS (ENTITIES ONLY)
                                           Robert Atchinson
-----------------------------------------------------------------------------
     (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP **
                                                                  (a)  [ ]
                                                                  (b)  [X]
-----------------------------------------------------------------------------
     (3)    SEC USE ONLY
-----------------------------------------------------------------------------
     (4)    CITIZENSHIP OR PLACE OF ORGANIZATION
                            United States
-----------------------------------------------------------------------------
NUMBER OF      (5)  SOLE VOTING POWER
                                                -0-
SHARES         ______________________________________________________________

BENEFICIALLY   (6)  SHARED VOTING POWER
                                                1,966,200
OWNED BY       ______________________________________________________________

EACH           (7)  SOLE DISPOSITIVE POWER
                                                -0-
REPORTING      ______________________________________________________________

PERSON WITH    (8)  SHARED DISPOSITIVE POWER
                                                1,966,200
-----------------------------------------------------------------------------
     (9)    AGGREGATE AMOUNT BENEFICIALLY OWNED
            BY EACH REPORTING PERSON
                                                1,966,200
-----------------------------------------------------------------------------
     (10)   CHECK BOX IF THE AGGREGATE AMOUNT
            IN ROW (9) EXCLUDES CERTAIN SHARES **                       [ ]
-----------------------------------------------------------------------------
     (11)   PERCENT OF CLASS REPRESENTED
            BY AMOUNT IN ROW (9)
                                                5.5%
-----------------------------------------------------------------------------
     (12)   TYPE OF REPORTING PERSON **
                                                IN
-----------------------------------------------------------------------------
                     ** SEE INSTRUCTIONS BEFORE FILLING OUT!






CUSIP No.  015351109                 13G                  Page 6 of 11 Pages

-----------------------------------------------------------------------------
     (1)    NAMES OF REPORTING PERSONS
            I.R.S. IDENTIFICATION NO.
            OF ABOVE PERSONS (ENTITIES ONLY)
                                           Phillip Gross
-----------------------------------------------------------------------------
     (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP **
                                                                  (a)  [ ]
                                                                  (b)  [X]
-----------------------------------------------------------------------------
     (3)    SEC USE ONLY
-----------------------------------------------------------------------------
     (4)    CITIZENSHIP OR PLACE OF ORGANIZATION
                            United States
-----------------------------------------------------------------------------
NUMBER OF      (5)  SOLE VOTING POWER
                                                -0-
SHARES         ______________________________________________________________

BENEFICIALLY   (6)  SHARED VOTING POWER
                                                1,966,200
OWNED BY       ______________________________________________________________

EACH           (7)  SOLE DISPOSITIVE POWER
                                                -0-
REPORTING      ______________________________________________________________

PERSON WITH    (8)  SHARED DISPOSITIVE POWER
                                                1,966,200
-----------------------------------------------------------------------------
     (9)    AGGREGATE AMOUNT BENEFICIALLY OWNED
            BY EACH REPORTING PERSON
                                                1,966,200
-----------------------------------------------------------------------------
     (10)   CHECK BOX IF THE AGGREGATE AMOUNT
            IN ROW (9) EXCLUDES CERTAIN SHARES **                       [ ]
-----------------------------------------------------------------------------
     (11)   PERCENT OF CLASS REPRESENTED
            BY AMOUNT IN ROW (9)
                                                5.5%
-----------------------------------------------------------------------------
     (12)   TYPE OF REPORTING PERSON **
                                                IN
-----------------------------------------------------------------------------
                     ** SEE INSTRUCTIONS BEFORE FILLING OUT!






CUSIP No.  015351109                 13G                  Page 7 of 11 Pages

Item 1(a).     Name of Issuer:

     The name of the issuer is Alexion Pharmaceuticals, Inc. (the "Company").

Item 1(b).     Address of Issuer's Principal Executive Offices:

     The Company's principal executive offices are located at 352 Knotter Drive,
Cheshire, CT 06410


Item 2(a).     Name of Person Filing:

     This statement is filed by:
           (i) Adage Capital Partners, L.P., a Delaware limited partnership
               ("ACP"), with respect to the shares of Common Stock directly
               owned by it;
          (ii) Adage Capital Partners GP, L.L.C., a limited liability company
               organized under the laws of the State of Delaware ("ACPGP"), as
               general partner of ACP with respect to the shares of Common Stock
               directly owned by ACP;
         (iii) Adage Capital Advisors, L.L.C., a limited liability company
               organized under the laws of the State of Delaware ("ACA"), as
               managing member of ACPGP, general partner of ACP, with respect
               to the shares of Common Stock directly owned by ACP;
          (iv) Phillip Gross ("Mr. Gross"), as managing member of ACA, managing
               member of ACPGP, general partner of ACP with respect to the
               shares of Common Stock directly owned by ACP; and
           (v) Robert Atchinson ("Mr. Atchinson"), as managing member of ACA,
               managing member of ACPGP, general partner of ACP with respect to
               the shares of Common Stock directly owned by ACP.

              The foregoing persons are hereinafter collectively referred to as
         the "Reporting Persons." Any disclosures herein with respect to persons
         other than the Reporting Persons are made on information and belief
         after making inquiry to the appropriate party.

Item 2(b).     Address of Principal Business Office or, if None, Residence:

     The address of the business office of each of the Reporting Persons is 200
Clarendon Street, 52nd Floor, Boston, Massachusetts 02116.

Item 2(c).     Citizenship:

     ACP is a limited partnership organized under the laws of the State of
Delaware. ACPGP and ACA are limited liability companies organized under the laws
of the State of Delaware. Messrs. Gross and Atchinson are citizens of the United
States.

Item 2(d).     Title of Class of Securities:

     Common Stock, par value $0.0001 (the "Common Stock")






CUSIP No.  015351109                 13G                  Page 8 of 11 Pages

Item 2(e).     CUSIP Number:

     015351109


Item 3. If this statement is filed pursuant to Rules 13d-1(b) or 13d-2(b) or
(c), check whether the person filing is a:

          (a) [ ]  Broker or dealer registered under Section 15 of the
                   Act,

          (b) [ ]  Bank as defined in Section 3(a)(6) of the Act,

          (c) [ ]  Insurance Company as defined in Section 3(a)(19) of
                   the Act,

          (d) [ ]  Investment Company registered under Section 8 of the
                   Investment Company Act of 1940,

          (e) [ ]  Investment Adviser in accordance with Rule
                   13d-1 (b)(1)(ii)(E),

          (f) [ ]  Employee Benefit Plan or Endowment Fund in accordance
                   with 13d-1 (b)(1)(ii)(F),

          (g) [ ]  Parent Holding Company or control person in accordance
                   with Rule 13d-1 (b)(1)(ii)(G),

          (h) [ ]  Savings Association as defined in Section 3(b) of the
                   Federal Deposit Insurance Act,

          (i) [ ]  Church Plan that is excluded from the definition of an
                   investment company under Section 3(c)(14) of the
                   Investment Company Act of 1940,

          (j) [ ]  Group, in accordance with Rule 13d-1(b)(1)(ii)(J).

     If this statement is filed pursuant to 13d-1(c), check this box:  [x]


Item 4.   Ownership.

      A. Adage Capital Partners, L.P., Adage Capital Partners GP, L.L.C. and
Adage Capital Advisors, L.L.C.
               (a) Amount beneficially owned: 1,966,200
               (b) Percent of class: 5.5% The percentages used herein and in
                   the rest of Item 4 are based on 35,740,970 shares of Common
                   Stock reported to be outstanding as of February 21, 2007, as
                   reflected in the Form 10-K filed by the Company on February
                   23, 2007.
               (c)(i) Sole power to vote or direct the vote: -0-
                 (ii) Shared power to vote or direct the vote: 1,966,200
                (iii) Sole power to dispose or direct the disposition: -0-
                 (iv) Shared power to dispose or direct the disposition:
                      1,966,200






CUSIP No.  015351109                 13G                  Page 9 of 11 Pages

      ACP has the power to dispose of and the power to vote the shares of
      Common Stock beneficially owned by it, which power may be exercised by
      its general partner, ACPGP. ACA, as managing member of ACPGP, directs
      ACPGP's operations. Neither ACPGP nor ACA own directly any shares of
      Common Stock. By reason of the provisions of Rule 13d-3 of the
      Securities Exchange Act of 1934 (the "Act"), ACPGP and ACA may be
      deemed to own beneficially the shares owned by ACP.

      B. Robert Atchinson and Phillip Gross
               (a) Amount beneficially owned: 1,966,200
               (b) Percent of class: 5.5%
               (c)(i) Sole power to vote or direct the vote: -0-
                 (ii) Shared power to vote or direct the vote: 1,966,200
                (iii) Sole power to dispose or direct the disposition: -0-
                 (iv) Shared power to dispose or direct the disposition:
                      1,966,200

              Messrs. Atchinson and Gross, as managing members of
ACA, have shared power to vote the Common Stock beneficially owned by ACP.
Neither Mr. Atchinson nor Mr. Gross directly own any shares of Common Stock. By
reason of the provisions of Rule 13d-3 of the Act, each may be deemed to
beneficially own the shares beneficially owned by ACP.

Item 5.   Ownership of Five Percent or Less of a Class.

     Not applicable.


Item 6.   Ownership of More than Five Percent on Behalf of Another Person.

     ACPGP, the general partner of ACP, has the power to direct the affairs of
ACP, including decisions respecting the disposition of the proceeds from the
sale of the shares. Messrs. Atchinson and Gross are the Managing Members of ACA,
the managing member of ACPGP, and in that capacity direct ACPGP's operations.

Item 7.   Identification and Classification of the Subsidiary Which Acquired the
Security Being Reported on by the Parent Holding Company.

     Not applicable.


Item 8.   Identification and Classification of Members of the Group.

     Not applicable.






CUSIP No.  015351109                 13G                  Page 10 of 11 Pages

Item 9.   Notice of Dissolution of Group.

     Not applicable.


Item 10.  Certification.

     Each of the Reporting Persons hereby makes the following certification:

          By signing below I certify that, to the best of my knowledge and
belief, the securities referred to above were not acquired and are not held for
the purpose of or with the effect of changing or influencing the control of the
issuer of the securities and were not acquired and are not held in connection
with or as a participant in any transaction having that purpose or effect.






CUSIP No.  015351109                 13G                  Page 11 of 11 Pages

                                   SIGNATURES

After reasonable inquiry and to the best of our knowledge and belief, the
undersigned certify that the information set forth in this statement is true,
complete and correct.


DATED:  April 2, 2007

                                     ADAGE CAPITAL PARTNERS, L.P.

                                     By: Adage Capital Partners GP, L.L.C.,
                                         its general partner
                                     By: Adage Capital Advisors, L.L.C.,
                                         its managing member

                                     /s/ Robert Atchinson
                                     -----------------------------
                                     Name:  Robert Atchinson
                                     Title: Managing Member


                                     ADAGE CAPITAL PARTNERS GP, L.L.C.
                                     By: Adage Capital Advisors, L.L.C.,
                                         its managing member

                                     /s/ Robert Atchinson
                                     -----------------------------
                                     Name:  Robert Atchinson
                                     Title: Managing Member


                                     ADAGE CAPITAL ADVISORS, L.L.C.

                                     /s/ Robert Atchinson
                                     -----------------------------
                                     Name:  Robert Atchinson
                                     Title: Managing Member


                                     ROBERT ATCHINSON

                                     /s/ Robert Atchinson
                                     -----------------------------
                                     ROBERT ATCHINSON, individually


                                     PHILLIP GROSS

                                     /s/ Phillip Gross
                                     -----------------------------
                                     PHILLIP GROSS, individually






                                    EXHIBIT 1

                           JOINT ACQUISITION STATEMENT

                            PURSUANT TO RULE 13d-1(k)

          The  undersigned acknowledge and agree that the foregoing statement on
Schedule  13G,  is  filed  on  behalf  of each of the  undersigned  and that all
subsequent  amendments  to this  statement  on Schedule  13G,  shall be filed on
behalf of each of the  undersigned  without the  necessity of filing  additional
joint  acquisition  statements.  The undersigned  acknowledge that each shall be
responsible for the timely filing of such  amendments,  and for the completeness
and accuracy of the  information  concerning  him or it contained  therein,  but
shall not be responsible  for the  completeness  and accuracy of the information
concerning the others, except to the extent that he or it knows or has reason to
believe that such information is inaccurate.



DATED:  April 2, 2007                ADAGE CAPITAL PARTNERS, L.P.
                                     By:  Adage Capital Partners GP, L.L.C.,
                                          its general partner
                                     By:  Adage Capital Advisors, L.L.C.,
                                          its managing member

                                     /s/ Robert Atchinson
                                     ------------------------------
                                     Name:  Robert Atchinson
                                     Title: Managing Member


                                     ADAGE CAPITAL PARTNERS GP, L.L.C.
                                     By:  Adage Capital Advisors, L.L.C.,
                                          its managing member

                                     /s/ Robert Atchinson
                                     ------------------------------
                                     Name:  Robert Atchinson
                                     Title: Managing Member


                                     ADAGE CAPITAL ADVISORS, L.L.C.

                                     /s/ Robert Atchinson
                                     ------------------------------
                                     Name:  Robert Atchinson
                                     Title: Managing Member


                                     ROBERT ATCHINSON

                                     /s/ Robert Atchinson
                                     ------------------------------
                                     Name:  Robert Atchinson


                                     PHILLIP GROSS

                                     /s/ Phillip Gross
                                     ------------------------------
                                     Name:  Phillip Gross