Kairos Pharma (NYSE American: KAPA) presented new preclinical data at the ASCO 2025 Annual Meeting on its investigational small molecule GITR ligand agonist, KROS101. The study, titled “Effect of KROS 101, a small molecule GITR ligand agonist, on T effector cells, T reg cells and intratumoral CD8 T cell cytotoxicity,” demonstrated KROS101’s dual mechanism of enhancing effector T cell activity while reducing immune-suppressive T reg cells. Results showed that KROS101 outperformed TRX518, a prior anti-GITR antibody, in promoting tumor infiltration, boosting cytotoxicity, and preventing T cell exhaustion. CEO Dr. John Yu emphasized the potential of KROS101 to advance cancer immunotherapy by simultaneously stimulating immune response and tumor destruction.
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About Kairos Pharma Ltd.
Based in Los Angeles, California, Kairos Pharma is at the forefront of oncology therapeutics, utilizing structural biology to overcome drug resistance and immune suppression in cancer. Its lead candidate, ENV105, is an antibody that targets CD105—a protein identified as a key driver of resistance to various cancer treatments. Elevation of CD105 in response to standard therapy results in resistance and disease relapse. ENV105 aims to reverse drug resistance by targeting CD105 and restore the effectiveness of standard therapies across multiple cancer types. Currently, ENV105 is in a Phase 2 clinical trial for castrate resistant prostate cancer and a Phase 1 trial for lung cancer, addressing significant unmet medical needs. For more information, visit the company’s website at www.KairosPharma.com.
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